An innovative technology termed isotopic ratio outlier analysis (IROA) was developed to overcome the analytical challenges associated with current, stable isotope labeled compounds used in untargeted /targeted metabolic profiling. These challenges minimally pertain to analytical variance, artifactual peaks, and metabolite identification. The IROA method uses metabolic incorporation of heavy (95% 13C) and light (5%…
As new technologies and applications to study environmental, food, water, and exposure contaminants advance, CIL continues to maintain a leadership role working with researchers to develop new standards to meet the latest needs. With new instrumentation and extraction procedures allowing detection limits approaching attogram levels in some cases, the need for highly accurate isotope standards has never been greater.
CIL offers a variety of metabolomic mixes and kits that are designed to aid ease of use in untargeted or targeted metabolomics (for quality control, qualification, and/or quantitation). The mixtures are offered neat or as solutions, while the kits are additionally supplied with a user manual. CIL can also provide customized mixes tailored to your specific needs.
Nucleic acids are necessary biomolecules of living systems being fundamentally important to a multitude of cellular processes. Its basic building blocks are nucleobases (e.g., adenine, cytosine, xanthine), nucleosides (e.g., adenosine, guanosine, inosine), and nucleotides (e.g., ATP, CDP, dGTP). The qualification/quantification of these compounds, and their synthetic analogs (e.g., 5-fluorouracil), in biosamples, is performed…
