Assessment of Neuronal Activity Using Microelectrode Array. The eCiphrNeuro assay uses primary cultures of rat cortical neurons. Cyprotex’s neuronal assay uses high throughput microelectrode array (MEA) technology to monitor electrophysiological activity. Neurons grown on microelectrode arrays recapitulate many features of neurons in vivo, including spontaneous activity (spiking and bursting), plasticity, organisation a…
In vitro ADME screening service Our in vitro ADME screening service offers a portfolio of assays for investigating: in vitro metabolism, in vitro permeability, solubility & physicochemical properties, toxicity, PK and bioanalysis. Cloe® Screen delivers consistent, accurate compound data with cost-efficiency that comes from a highly automated approach. • Highly reproducible, accurate data - validated and used by over 200 Pharma…
Bespoke ADME and DMPK experimental service Our Cloe® Select ADME and DMPK experimental service is designed to meet the requirements of later stage studies. Services include: in vitro metabolism, in vitro permeability, plasma protein binding, solubility, physicochemical properties, PK and bioanalysis. Cloe® Select offers the following benefits: • Flexibility - a portfolio of bespoke studies which can be customised to individual…
Cloe® PK - Pharmacokinetic prediction using PBPK modelling Cloe® PK is an innovative software system that uses PBPK modelling for pharmacokinetic prediction. By integrating physicochemical and ADME screening data, Cloe® PK can predict the levels and duration of drugs in blood, major tissues and organs. Human intestinal absorption model Cloe® Predict Human Intestinal Absorption Model is a reliable physiological model which uses…
