Drug discovery > Target Discovery Products & Reviews
Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
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Sigma-Aldrich® CRISPR synthetic gRNAs
MerckSigma-Aldrich ® one-part sgRNA and two-part crRNA:tracrRNA systems accelerate genome editing with Cas9 protein, mRNA, or established Cas9 expressing cell lines. Our guides are compatible with a variety of delivery methods including microinjection, electroporation, and lipofection.
Sigma-Aldrich® Cas9 proteins
MerckWith the largest portfolio of Cas9 proteins available, Merck make it easy to find the perfect nuclease for your gene editing experiment.
MISSION® shRNA Clones
MerckThe largest and most validated shRNA collection from the RNAi consortium (TRC). Merck's unique shRNA formats leverage the discovery potential of the trusted and proven TRC shRNA collection. When you partner with them, you gain access to their world class lentiviral production expertise and the formats and specifications for RNAi knockdown experiments at any scale.
3dGRO™ Patient-Derived Organoid Gastrointestinal Biobank
MerckA comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients.
CRISPRi Libraries, Pools, and gRNAs
MerckNuclease-independent applications of CRISPR provide equal targeting specificity but instead of cutting, CRISPRi allows for targeted interference of gene function by delivering transcriptional repressor domains to a specific target sequence using modified dCas9 + gRNA complexes. Gene knockdown is complementary to CRISPR-KO and CRISPRa (activation) and has distinct advantages over existing loss-of-function strategies like RNAi.…
Gastrointestinal Organoid Biobank
MerckPatient-derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology.
T7E1 CRISPR Validation Kit
MerckThe T7 Endonuclease Detection Assay is a well-known method for detecting genome editing events from CRISPR, Zinc-finger nuclease, and TALEN gene targeting. Originally identified from Escherichia coli bacteriophage, the T7 endonuclease can cleave mismatched heteroduplex DNA, Holliday junctions, branched DNA, and cruciform DNA.
CRISPR Plant
MerckAll-in-one, ready-to-use Cas9 and guide RNA (gRNA) expression plasmids for use with monocots and dicots.