MISSION® TRC3 Human LentiORF Collection
MerckPooled and Arrayed Genome-Wide LentiORF Libraries for High-Throughput Screens or Targeted Experiments
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PURedit™ Protein
MerckRecombinant PURedit Cas9 protein from Streptococcus pyogenes is a ready-to-use reagent for genome engineering experiments
Cas9 Plus Protein
MerckRecombinant Cas9 Plus protein from Streptococcus pyogenes is a ready-to-use reagent for genome engineering experiments.
Cas9-GFP Protein
MerckRecombinant Cas9-GFP protein from Streptococcus pyogenes is a ready-to-use reagent for genome engineering experiments.
MISSION® TRC Arrayed shRNA Library
MerckTrusted TRC (The RNAi Consortium) content with shRNA targting 20,000+ human or 21,000+ mouse genes including TRC 1.5 and 2.0 (unique and validated) add-ons which are exclusive to Sigma
CompoZr® Oncology Disease Model Cell Lines
MerckWe have applied CompoZr Zinc Finger Nuclease technology to create an unparalleled range of genetically modified mammalian cell lines for use in areas, such as target validation, drug discovery and drug development.
CompoZr® Reporter Cell Lines
MerckCompoZr ® ZFN (zinc finger nuclease) technology was used to insert the sequence for fluorescent proteins adjacent to endogenous genes to create reporter cell lines for compound screening
Caco-2 Cells
MerckEnable assessment of drug transport by comparison between the wild-type (WT) and knockout cell lines
AAVS1 Safe Harbor Landing Pad Cell Lines
MerckA pre-engineered cell line with integrated genetic elements for simple payload exchange of your specific promoter and gene of interest. The landing pad construct is targeted to the AAVS1 safe harbor locus with a fluorescent marker for downstream screening.
Human CRISPR Brunello Knockout Library
MerckThe human CRISPR ′Brunello′ pooled library is designed using optimized metrics, as published by, Doench et al. Nat Biotechnol. (2016) and described further in Sanson, K.R., et al. Nat Commun (2018)