Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
Enhance existing mass spectrometry pipelines by integrating in-source field asymmetric ion mobility spectrometry (FAIMS) ino separation capabilities. ultraFAIMS adds orthogonal separation capacity to existing chromatography/mass spectrometry systems enabling enhanced compound detection and quantification.
Reliable in vivo breath sample collection of VOCs and respiratory droplets for biomarker identification and validation. Suitable for use in a range of contexts and diverse applications including early detection, drug development and precision medicine for conditions including respiratory diseases, liver diseases and cancer. Compatible with a range of analytical systems including GC-MS analysis with Breath Biopsy Services.
Combining high resolution accurate mass mass spectrometry and world-leading breath analysis expertise to offer complete breath biomarker discovery and validation solutions. Breath Biopsy Services provide versatile Breath Biopsy sample analysis and reporting driven by GC-Orbitrap technology and supported by a rigorous quality assurance process ensuring reliable, high sensitivity VOC biomarker detection.
Exogenous volatile organic compound probes (EVOC Probes) enable targeted, non-invasive assessment of biological pathways. Probes are safe, easy to administer compounds that interact with characterised metabolic pathways with relevance to key disease areas. Using Breath Biopsy, EVOC Probes can be monitored non-invasively on breath, either alone or in parallel with biomarker discovery studies.
A targeted panel of compounds with established relevance for respiratory diseases enabling high confidence, non-invasive disease detection and monitoring. Each compound is supported by evidence from breath research studies of relevant respiratory diseases and disease processes. The panel is available as an aspect of Breath Biopsy Services and panels for other disease applications are in development.
Identify prospective biomarkers relevant to key disease processes through in vitro GC-MS analysis. Compatible with headspace sampling from cell cultures, macromolecular preparations and ex vivo samples. Driven by GC-Orbitrap high-resolution mass spectrometry and supported by a rigorous and comprehensive quality assurance process. Results are suitable for comparison with in vivo studies using Breath Biopsy Services.
Consumable components of the Breath Biopsy system, required for robust breath sample collection using the ReCIVA Breath Sampler as part of the Breath Biopsy Collection Station. One Kit per sample.
Reliable and reproducible, non-invasive Breath Biopsy sample collection for high-accuracy analysis of human breath. ReCIVA provides high quality sample collection alongside ease-of-use and patient safety and comfort. Samples are easy to store and transport and can be analysed using a wide range of techniques. We recommend processing Breath Biopsy samples using high-accuracy GC-MS, available through Breath Biopsy Services.
A versatile and easy to use analyzer for the detection of biomarkers in clinical samples using field asymmetric ion mobility spectrometry (FAIMS). Rapid, portable, sensitive and selective, Lonestar has wide-ranging applications for the detection and quantification of volatile organic compounds (VOCs) from a variety of sample types including feces, urine and breath.
