Drug discovery > Basic Research Products & Reviews

Magnet+ ensures a simple and reliable method of purifying genomic, plasmid and mitochondrial DNA, using magnetic beads.

Achieve quick, clean, and complete protein digestion

Waters offers a broad range of vials, each one is held to tight dimensional tolerances and the certified products have cleanliness measured by LC and MS.LC/GC Certified vials are tested by LC/UV for residues of chemicals used in processing and packaging vials. The septa are tested by headspace GC to ensure low levels of low molecular weight polymer. These vials are suited for analyte concentration in the µg/mL concentration; t…

The Waters IdentityE High Definition Proteomics system defines the new standard for rigorous protein identification. The IdentityE High Definition Proteomics System is an UltraPerformance LC® (UPLC)/High-Bandwidth Mass Spectrometry (MS E) system solution suitable for confident protein identification designed to meet stringent requirements as outlined by leading scientific journals.The new Waters IdentityE High Definition Pro…

Developed for your most demanding LC/MS/MS quantitative applications, the Quattro Premier™ XE tandem quadrupole mass spectrometer features the highest levels of sensitivity, selectivity, robustness, speed and accuracy. To maximize the analytical advantages of your ACQUITY UPLC® System, the Quattro Premier XE operates at the highest data acquisition rates. Together, the ACQUITY UPLC® System and the Quattro Premier XE give you i…

The Mass Spectrometry Primer, an 82-page paperback book, covers a wide range of topics related to the most wide spread of modern mass spectrometry practices and answers some frequently asked questions about the use and capabilities of mass spectrometers. Links are also provided to articles for more in-depth reading. The first section examines who uses mass spectrometers, followed by how compounds are ionized in the source to b…

The Quick Western Kit provides a universal detection reagent that can be combined with the primary antibody incubation step, eliminating the need for a secondary antibody incubation step.

IRDye 680RD is the near-infrared fluorescent dye of choice for applications in the 700 nm wavelength, especially Western blots, cell-based assays such as the In-Cell Western assay, and small animal imaging experiments.

Odyssey One-Color Protein Molecular Weight Markers fluoresce in the 700nm channel of any of the Odyssey Imaging Systems and contain ten protein bands of 10, 15, 20, 25, 37, 50, 75, 100, 150, and 250 kDa, with molecular weight shifts of 5% and minimal band broadening.

LICORbio Western Blotting Kits provide a convenient way to purchase reagents and membranes that are optimized for infrared fluorescence detection on the Odyssey infrared imaging systems.

IRDye QC-1 is the first non-fluorescent (dark) quencher, compatible with a wide range of visible and near-infrared fluorophores (~500 – 800 nm).

The CellTag™ 700 Stain ICW (In-Cell Western™) Kits provide detection reagents for cell-based In-Cell Western Assays.

The Odyssey® Infrared EMSA Kit coupled with IRDye® 700 EMSA oligonucleotides is an excellent alternative method to radioisotopic and chemiluminescent detection methods for EMSA analysis and visualization. Using IRDye EMSA reagents, assays can be completed in less than two hours with no gel transfer or film exposure.

A DNA oligonucleotide end-labeled with IRDye 700 infrared dye is a good substrate for protein binding. Using the Odyssey Infrared Imaging System, IRDye infrared dye labeled DNA detection is linear within a 50-fold dilution range from 9.1 fmol to 0.18 fmol.

IRDye® Click Chemistry reagents (DBCO, Alkyne, and Azide) offer convenient, versatile and reliable methods for biomolecule labeling. With a variety of in vitro and in vivo applications, from biomarker isolation to assay development.

IRDye Infrared Dyes and near-infrared (NIR) fluorescent imaging deliver enhanced sensitivity due to low background autofluorescence in the near-infrared region, therefore, giving a higher signal to noise ratios.

WesternSure chemiluminescent reagents offer the best performance available when compared to other competitive products on the market.

When performing two-color detection, loading controls and normalization are essential for reliable, precise comparison of protein levels. LICORbio offers primary antibodies for normalization that can be used for two-color normalization when performing multiplex Western blots or for cell-based assay normalization.

A low-background membrane is essential for infrared Western blot success. Background can be attributed to membrane autofluorescence or to detection of antibody non-specifically binding to the membrane. PVDF membranes included in LICORbio kits are screened to ensure low autofluorescence to ensure high signal to noise.

WesternSure ECL Stripping Buffer provides a robust solution for stripping primary and secondary antibodies from Western blot membranes while maintaining target antigen integrity for efficient reprobing.

NewBlot IR Stripping Buffer is ideal for stripping and reprobing nitrocellulose and PVDF membranes detected with IRDye ® secondary antibodies. It may also be suitable for other dye-conjugated secondary antibodies.

CellTag 700 Stain is a near-infrared fluorescent, non-specific cell stain that provides accurate normalization to cell number for In-Cell Western™ Assay applications. The stain accumulates in both the nucleus and cytoplasm of permeabilized cells, and provides linear fluorescent signal across a wide range of cell types and cell numbers.

Chameleon®  Pre-Stained Protein Ladders offer easy visualization of gel migration and protein size, and can be used to orient your gel or membrane quickly. These versatile protein markers offer multi-colored, pre-stained proteins for both visual inspection and two-color near-infrared detection. Choose from either single-channel or two-channel detection.

The WesternSure Protein Ladder is the only pre-stained, multi-colored protein ladder that provides chemiluminescent signal for film and digital detection. It will fit with your current protocol without optimization and does not rely on strep-tagged HRP or secondary antibody binding. The WesternSure protein ladder works with a variety of substrates and provides a vibrant color scheme that allows you to quickly orient your membr…

The D-DiGit Gel Scanner offers complete nucleic acid gel analysis documentation without the hazards. Minimize exposure to hazards like UV light and ethidium bromide when image nucleic acid gels.