Drug discovery > Basic Research Products & Reviews

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Products, services, reviews and techniques used in the preliminary investigations of the disease; the cell biology, genetics and protein pathways using tissue culture, cloning and imaging.

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ResPep SL

Intavis Inc.

The ResPep SL is a fully automated tabletop peptide synthesizer. The chemistry is optimized for Fmoc-based peptide synthesis with standard activation by PyBOP, HBTU, DIC/HOBt or a similar protocol. Additional modules for large scales, micro scale and SPOT synthesis are available.

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DigestPro MSi

Intavis Inc.

Enzymatic digestion of proteins in polyacrylamide gel slices and subsequent analysis of the peptides by mass spectrometry has become a routine procedure in protein analysis. In solution digestion protocols for bottom-up proteomics complement it. The DigestPro MSi automates all those procedures to achieve high throughput under controlled and reproducible conditions.

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xxpress™ Thermal Cycler

BJS TECHNOLOGIES

With a uniform thermal ramp rate of over 10°C per second xxpress™ is the fastest real-time thermocycler in the World delivering 40 cycle q-PCR in under 10 minutes. And whilst not all PCR chemistries are yet as fast as this system there are a number that repeatably and reliably work at this speed. Ultra low thermal mass and high conductively enable the patented resistive heating system deliver this speed cycle more efficiently…

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Quantikine® ELISA Kit for Measuring High Molecular Weight Adiponectin

Bio-Techne

R&D Systems now offers a Quantikine ELISA Kit for measuring high molecular weight (HMW) Adiponectin/Acrp30 in serum or plasma. This is the first commercially available ELISA designed to measure HMW Adiponectin without the need for proteolytic pretreatment of the sample. HMW Adiponectin is the primary bioactive form with insulin-sensitizing activity. Its circulating levels negatively correlate with obesity, insulin resistance,…

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QBC ParaLens Advance Fluorescent Microscope Attachment

Woodley Equipment Company Ltd

The QBC ParaLens Advance microscope attachment is a unique solution to fluorescence microscopy in that it combines the critical components of an epi-fluorescence microscope, namely the light source and filter set, with a microscope objective in a compact, durable format that can transform virtually any compound light microscope into an epi-fluorescence microscope. Utilising LED technology, the ParaLens light source lamp has a…

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Immunoassay Microtiter Microplates

Thermo Fisher Scientific

Advanced features and careful design ensure the reliability of Microtiter microplates. In your immunoassays coating and washing are always even, and the recessed bottom keeps the surface clean and scratch free ensuring high optical performance. The microplates are available with different binding characteristics and formats.Product detail:Thermo Microtiter products have binding characteristics that include ImmulonTM hydrophobi…

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Luminescence Microtiter Microplates

Thermo Fisher Scientific

White Microtiter microplates are designed for use with light emitting markers. Pigments have been carefully selected to optimize assay performance. The white pigment eliminates cross talk while optimum reflection enables best performance in luminometric applications with low signals. These microplates are available in different formats and binding characteristics. Product detail: Thermo offers a selection of Microtiter micro…

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Fluorescence Microtiter Microplates

Thermo Fisher Scientific

Thermo black and white microplates help you to optimize your assay performance in fluorescent applications. These microplates are designed for use with light emitting markers, having carefully selected pigments to eliminate cross talk and reduce background signals of your assays. Different binding characteristics and formats are available. Product detail:Microtiter Microfluor microplates and universal/enhanced binding plates…

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Clear Bottom Microtiter Microplates

Thermo Fisher Scientific

These clear bottom microplates are sterile and thus ready to cultivate bacteria and fungi. TC treatment makes them perfect for mammalian tissue culture with no need for chemical treatments. They are individually packaged with lid and their unique design helps to eliminate cross-talk. The microplates are perfect for microscopic viewing and also suitable for top and bottom reading instruments. Low background fluorescence and lum…

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UV Microtiter Microplates

Thermo Fisher Scientific

Thermo UV microplates are designed specially for your applications adapted for the UV wavelength area. The performance is optimal down to at least 220 nm with fairly low absorbance background. Thus nucleic acid and protein determinations using this microplate made of UV light transmitting material are enabled at 260/280 nm. The microplate is also compatible with any standard microplate reading or liquid handling device. Produ…

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Coated Microtiter Microplates

Thermo Fisher Scientific

Streptavidin coated wells of the BioBind microplate offer biotin mediated binding for small or hydrophilic molecules. This surface is ideal for e.g. peptides, oligonucleotides and DNA hybridization assays. The streptavidin-biotin bond is extremely strong and stable, and utilizing this system problems associated with steric hindrance during the binding procedure can be avoided. Product detail: BioBind - Streptavidin Coated…

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ORCA-Flash4.0 Camera

Hamamatsu Corporation Camera Products Group

Hamamatsu’s brilliantly designed ORCA-Flash4.0 is truly a game changer in the world of scientific imaging. Built on a revolutionary new Gen II sCMOS detector, the ORCA-Flash4.0 is the first sCMOS camera that challenges the performance of all CCD, EM-CCD, and Gen I sCMOS cameras. With its combination of low noise and high quantum efficiency, the ORCA-Flash4.0 delivers unprecedented sensitivity as well as high dynamic range, bla…

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SeqSolve Integromics

Integromics

SeqSolve™ is an advanced and user-friendly software solution for the tertiary analysis of Next Generation Sequencing (NGS) data. By integrating state-of-the-art bioinformatics methods into one-click analysis workflows, SeqSolve is the only software able to provide scientists with such a combination of both cutting edge and intuitive user experience. Its Click And Go® technology enables the automatic processing of the data, whi…

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Corning® 5 mL Internal Threaded Polypropylene Cryogenic Vial, Self-Standing with Round Bottom

Corning Life Sciences

5 mL capacity with round bottom Self-standing design Black graduations and larger marking spots for easier filling and sample identification Manufactured from polypropylene to withstand temperatures to -196°C Silicone washer for a secure seal Vials may be color coded with inserts (see Cat. No. 430499) Special base design allows vials to be locked into cryogenic rack and tray (Cat. No. 430525 or 431131) for single-hande…

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Arrayed BAC library

Bio S&T

An arrayed or non-arrayed BAC library is the preferred choice for downstream applications such as hybridization screening; full-genome sequencing; BAC end sequencing or physical mapping projects. Amount of clones received is based on a guaranteed coverage and 120Kb average insert size. HMW DNA isolation and QC by HMW DNA enzymatic digestion are included. Deliverables for ARRAYED BAC library: Clones will be arrayed and amplifie…

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Screened BAC library

Bio S&T

A pooled BAC library is an invaluable tool for PCR-screening. It allows for the easy retrieval of BAC clones of interest. This type of library is especially useful when genome size is large and creating an arrayed library is cost-prohibitive. We typically construct a minimum 5X BAC library and BAC clones are then pooled and distributed in 96-well plates. Each well will contain about 400-500 original BAC clones. HMW DNA isolati…

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Normalized cDNA libraries

Bio S&T

Our cDNA libraries feature full-length-enriched and high quality size-fractionated cDNA. cDNA library construction is usually done in slightly-modified versions of pBluescript or pcDNA3.1. Insert sizes will range from about 0.5Kb to 4Kb. Concerning QC steps, we evaluate the average insert size, empty clone rate and clone concentration/tube before shipping out. We always provide a gel picture of randomly selected clones showing…

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APAgene™ GOLD Walking Kits

Bio S&T

APAgene™ GOLD Genome Walking Kits are designed to rapidly and reliably amplify unknown genomic DNA using our patented APA technology: 1. Isolate unknown genomic sequences flanking transgenes (including T-DNAs, gene traps, transposons), sequence-tagged sites (STSs) or expressed sequence tags (ESTs). 2. Isolate localized sequences flanking known sequences from large clones and genomic DNAs. 3. Sequence insert ends of large clone…

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ASH cDNA Subtracted Library

Bio S&T

ASH is APA-based, full-length-enriched, single-stranded cDNA subtraction hybridization library. - ASH cDNA subtraction is full-length-enriched and independent of PCR suppression. - ASH cloning is directional and does not involve normalization. - ASH method provides non-exponential amplification before subtraction because double-stranded cDNA is not required. - ASH method has a better subtraction effect because 1) a high ratio…

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RNA Isolation for Sequencing

Bio S&T

Bio S&T's high-quality RNA can be used directly for NxGen RNA sequencing as well as other downstream applications that require optimal-quality RNA such as quantitative real-time RT-PCR, microRNA cloning and amplification and Northern blotting.

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Retroviral Research Products

Bio S&T

Bio S&T is the only commercial provider of highly purified human tRNAs. RNA is most widely used as the primer of retroviral reverse transcriptases. The 3’ end of the tRNA binds to the complementary binding site on the viral RNA therefore initiating reverse transcription. 1. tRNALys3 is the primer of HIV-I, HIV-II, SIV and FIV. 2. tRNALys1,2 are the primers of BLV, HTLV-I and II, SSV, FLV, VV, CAEV, MPMV, SMR and EIAV. 3. tRNAT…

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RealTime Ready Assays

RealTime ready Custom RT-qPCR Assays and Panels Get a head start on your gene expression analysis with function tested assays for all annotated human, mouse, and rat genes Achieve high specificity using intron-spanning assays based on short hydrolysis LNA-substituted Universal ProbeLibrary (UPL) Probes.  Rely on stringently RT-qPCR-tested assays that are compliant with MIQE (Minimum Information for Publication of Quantitati…

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x-tremeGENE DNA Transfection Reagents

Improve your cell analysis and use our powerful new transfection reagents: Efficiently transfect a broad spectrum of cells, including difficult-to-transfect cell lines and tumor cell lines. Generate physiologically relevant results using low cytotoxic reagents. Avoid time-consuming optimization using fast, reliable protocols.

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