Drug discovery > Basic Research Products & Reviews

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An easy way to assess tag accessibilityThe production of fusion proteins often raises the issues not only of their structural integrity after isolation, but also of the accessibility of the associated tag. In the case of GST or 6HIS tagged proteins, this verification can be achieved with HTRF® GST and 6HIS check kits. These two assays are competitive immunoassays in which the anti-GST or anti-6HIS Cryptate conjugates bind dire…

A new secondary messenger for Gq coupled receptor investigation.Cisbio’s IP-One assay, based on its proprietary HTRF® technology, is the first HTS immunoassay that can easily detect inositol(1)phosphate (IP1), a stable second messenger which tightly correlates with Gq-coupled receptor activity. This assay displays all the characteristic advantages of an HTRF® system: totally homogeneous, detection via fluorescence, signal stab…

The Dimension-M1™ Raman MicroscopeLambda Solutions now provides a unique coupling of its Dimension series Raman systems to Nikon or Olympus microscopes. The result is a high performance Raman microscope at an extraordinary value. The Dimension-M1™ is available as an integrated unit, or as a Dimension-P1™ Raman System with the addition of a microscope and a Raman Microscope Adapter.  This system is available with the high spati…

Rapid Analysis of Multiple 2D Gel Sets DYMENSION 2 has all the features of DYMENSION 1 but has the added ability to detect and compare protein spot maps in multiple gel sets. The software offers many background correction and noise filtering features including a SYPRO® Ruby filter, which can detect and automatically remove spots caused by SYPRO® Ruby crystals adhering to the gel, thus saving users valuable time editing the…

Quick and Easy Analysis of all 2D Gel Applications The exciting DYMENSION 3 software has all the functionality of DYMENSION 2, so can be used to analyse multiple gel sets. In addition, DYMENSION 3 is capable of analysing multi-stained fluorescent gel images stained with up to three contrasting fluorescent labels, for example, Cy™2, Cy™3 and Cy™5. This feature allows users to analyse multiple sets of any type of 2D protein…

Nuclease-free water is prepared using diethylpyrocarbonate (DEPC) to ensure the removal of RNase contamination. RNase-free, sterile, optimised for molecular biology applications.

Made of thin wall polypropylene and designed to fit on all Corning® Thermowell™ GOLD 1 x 8 well PCR strips and 96 well PCR microplates DNase- and RNase-free Autoclavable at 121°C

VeroFect™ is a powerful reagent dedicated to the transfection of Vero cells. This lipid -based transfection reagent is issued from the revolutionary Tee-Technology and achieves up to 50-55% transfection efficiency. The complexes formed by DNA and VeroFect™ reagent have an exceptional capacity in destabilizing cell membranes, allowing the delivery of important DNA amounts into cells. VeroFect™ was specifically designed to obtai…

Bottoms are 60% thinner than conventional polystyrene plates, resulting in lower background fluorescent and enabling readings down to 340nm Designed to reduce well-to-well crosstalk during fluorescent assays Can be used for both top and bottom reading instruments Not treated (or medium binding) polystyrene surface is hydrophobic in nature and binds biomolecules through passive interactions Is suitable primarily for the i…

The REMP Portrait Heat Sealer is a completely electro-mechanical, thermal sealing instrument that does not require any air or vacuum to operate. This versatile and efficient instrument accommodates deepwell, assay, PCR, and standard microplates with only a minor adapter change. The REMP Portrait Heat Sealer uses any of the various rolls of REMP’s Thermo-Seals, most of which are resistant to DMSO, as well as, other solvents and…

Very economical untreated PVC microplates for solution-based assays, serial dilutions, and general storage applications Well volume of 250 µL; recommended working volume of 50 to 150 µL Lids are not available

High binding surface binds medium (>10kD) and large biomolecules that possess ionic groups and/or hydrophobic regions Binding capacity of approximately 500ng of mouse IgG/cm2 Ideal for immunoassays Certification results for each lot are made available upon request by contacting local Corning Life Sciences office Recommended working volume of up to 75 to 200 µL Conforms to standard microplate footprint and dimensions Wi…

Reusable orange polycarbonate box holds 81 cryogenic vials in a 9 x 9 array For use with 4 - 5 mL vials Ridges on sides of box make them easier to grip while wearing gloves

Extract and label proteins from extremely limited sample sizes The first commercially available nanoscale buffer kit for antibody arrays Minimal background for high signal-to-noise ratios Optimized for use with the Clontech™ Ab Microarray 500 Kimberly Milner and Dmitry Bochkariov, Ph.D. The Clontech™ Antibody Array Nanoscale Buffer Kits designed for those who have limited amounts of sample and want to assay hundreds…

A line of Elisa kits, optimized and disposable, fully standardized againts the NIBSC standard. A line of CE marked assay, which fit the best your laboratory requirements. Assays insensitive to the interference of rheumatoid factor.

The Zymutest line of reagents is a ready to use and complete line of enzyme immuno assay, using 96 well microElisa plates, disposable in 12X8 well strips. The include Calibrators and controls.

The Zymutest line of Elisa kits are ready to use. Complete line of Enzyme Immuno assays, using 96 well microElisa plates, disposable in 12X8 well strips. Made for the exploration of plasma factors, fibrinolysis, autoimmunity, and markers of thrombotic diseases. They all include calibrators and controls.

Zymutest Elisa assays for measuring different Cardiovascular disease markers. CRP, tPA, PAI-1, Lp(a)

Herculase II Fusion DNA Polymerases Pfu Ultra DNA Polymerases & PCR Master Mixes PfuUltra II Hotstart DNA Polymerases & PCR Master MixesHerculase II Fusion DNA PolymerasesThe Herculase II fusion DNA polymerase produces superior yields with extension times as short as 15 sec/kb (see Figure), even with genomic DNA targets up to 12kb. Herculase II fusion DNA polymerase helps overcome PCR challenges with successful amplification o…

The Optoscan monochromator from Cairn Research is the only instrument of its type to offer control of both centre-wavelength and bandwidth with millisecond time resolution. Combined with Cairn signal processing modules and optical hardware it forms the heart of a powerful and flexible microfluorescence system. Alternatively it can be readily integrated into commercial imaging systems, or custom controlled for bespoke applicati…

Thermo Scientific* Fermentas PCR Master Mix is a 2X concentrated solution of Taq DNA Polymerase, dNTPs and all the components required for PCR, except DNA template and primers. This pre-mixed formulation saves time and reduces contamination due to a reduced number of pipetting steps required for PCR set up. The mix is optimized for efficient and reproducible PCR. ■ Convenient—Taq DNA Polymerase in a ready-to-use mix ■ Fast—sa…

Versatile single and double beam spectrophotometers pre-programmed with food and beverage analyses.

Product Type: antibody. Immunogen: native, from brain. Host: mouse. Type: monoclonal. Clone: 31A3. Subclass: IgG1. Format: affinity purified Ig. Preparation: prepared by Protein A chromatography. State: liquid. Buffer: PBS buffer, pH 7.2, 0.1% Sodium Azide. Storage: aliquot and store at -20°C.Cross reactivity Reacts with PGP 9.5 from human and rat. Tissue reactivity Stains neuronal cell bodies and axons in the CNS and peripher…

Product Type: antibody. Immunogen: native, from plasma. Host: mouse. Type: monoclonal. Clone: 10-11. Subclass: IgG1-k. Format: affinity purified Ig. Preparation: Protein A chromatography. State: liquid. Buffer: borate buffered saline, pH 8.4, 0.1% sodium azide. Storage: aliquot and store at -20°C.Cross reactivityDoes not react with C4c. Does not cross react with cow, cat, dog, guinea pig, mouse, rabbit, sheep or rat.Specificit…