Drug discovery > Lead Discovery Products & Reviews

High-Resolution, Strong and Weak Anion-Exchange Columns for the Separation of ProteinsThe ProPac® SAX-10 is a nonporous, strong anion-exchange column (quaternary amine functional group). The ProPac WAX-10 column is a weak anion exchanger (tertiary amine functional group). Both are based on a nonporous core particle that provides pressure stability. A hydrophilic layer prevents unwanted secondary interactions and a grafted anio…

Strong and Weak Cation-Exchange Columns for High-Resolution Separation of Proteins and MAbsThe Thermo Scientific ProPac™ SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency peaks and high-resoluti…

For Hydrophilic Anionic Protein SeparationsThe ProPac® PA1 column supports the analysis and purification of hydrophilic anionic proteins and peptides. Proteins and peptides that are highly cationic (e.g., those with very high isoelectric points) may be resolved on this column, but some may exhibit substantial binding to the column.ProPac® PA1 Protein and Peptide Column Features: Good for hydrophilic anionic proteins and pepti…

Hydrophobic Interaction Chromatography Columns for the Separation of Large BiomoleculesHydrophobic Interaction Chromatography separates biomolecules in a decreasing salt gradient, based on differences in surface hydrophobicity. This method preserves the biological activity of proteins. The HIC separation mechanism is complementary to those of ion-exchange and gel filtration chromatography.The ProPac® HIC-10 column is a high-re…

ProSwift™ ConA-1S Affinity Column for Glycan, Glycopeptide and Glycoprotein Enrichment and Purification The ProSwift ConA-1S affinity monolith column is unsurpassed for fast, highly efficient enrichment and purification of Concanavalin A (Con A) binding glycans, glycopeptides, and glycoproteins from complex samples.The HPLC- compatible ProSwift ConA-1S affinity column maintains the specificity and selectivi…

Monolith Reversed-Phase Columns for High-Resolution Protein Separations at High Flow Rates ProSwift® reversed-phase monolith columns uniquely provide the advantages of high resolution at exceptionally high flow rates for protein separations. They deliver the outstanding resolving power of nonporous analytical media combined with faster separations than any bead based columns available. ProSwift polymer monolith columns achieve…

Monolith Ion-Exchange Columns for Superior High-Resolution Analytical and Preparative Protein Separations The ProSwift SCX monolith column line has been expanded to include a new 1 x 50 mm column. As with all ProSwift monoliths, the fast mass transfer allows for fast protein separations. ProSwift monoliths offer excellent separations using fast gradients at low and high flow rates, which improve productivity.ProSwift Monolith…

Finneran’s patented 96-Well Multi-Tier Micro Plate offers an improvement on existing 96-well systems. The unique design provides maximum diversity for many different applications. The Finneran plate can have a fixed height or it can be multi-tiered for adjustable height to support different sized vials and sampling volumes. The plate can be built using spacers, to hold vial capacities of 0.5mL, 1.0mL, 1.5mL, and 2.0mL dependin…

J.G. Finneran's EZ-Pierce 96-Well Template Sealing FilmJ.G. Finneran offers sealing films designed for microplates where well to well contamination and cross over is of critical concern.  Our easy piercing film allows for direct sample recovery with a mulit-channel pipettor or robotic probes.  No longer is there a need to peel back the film in order to access the wells and risk aerosols and possible contamination and cross-ove…

J.G. Finneran's Sealing Mats for 96-Well MicroplatesJ.G. Finneran's molded Teflon/Silicone and Silicone only Sealing Mats are designed to fit standard 96-well microplates with cylindrical or tapered wells, and square wells.  The tight seal prevents sample cross contamination and the liner reseals after multiple injections thus reducing the chance of solvent evaporation.  The liners are made from Teflon lined medical grade sili…

The Mosaic ELISA Human Cytokine Panel 1 is an excellent tool for the detection of 8 different cytokines in the same sample. Mosaic ELISA kits employ multiplex microarray technology to provide an accurate, efficient, and economical alternative to conducting multiple traditional ELISA experiments. Cytokines are pleiotropic extracellular signaling molecules that influence myriad physiological and pathological processes. Released…

J.G. Finneran's new 96-well aluminum base microplate combines the advantage of the vented design of the original Multi-Tier Microplate which assures uniform heating and cooling when immersed in a water bath with the ability to efficiently freeze dry samples when required, due to the aluminum material.  The aluminum microplate promotes more efficient heat transfer which is important to the freeze drying process. The aluminum m…

The EPL picosecond pulsed diode lasers are a new excitation source for fluorescence lifetime measurements that bridge the gap between the nanosecond flashlamp and expensive mode locked Titanium Sapphire femtosecond lasers. The EPL lasers are pre-adjusted for an optimum pulse width, with particular attention paid to reducing a secondary shoulder. The output has a guaranteed pulse width of less than 100 picoseconds. The EPL lase…

The EPLED picosecond pulsed LEDs are a new excitation source for fluorescence lifetime measurements. In Time Correlated Single Photon Counting (TCSPC), they bridge the gap between the nanosecond flashlamp and expensive mode locked Titanium Sapphire femtosecond lasers in the UV region. The EPLEDs are pre-adjusted in respect to pulse width and peak power, with particular attention paid to reducing both secondary shoulder and a l…

DATAN 3.0OverviewWith DATAN 3.0 characterization of chemical equilibria and chemical reactions becomes easy. DATAN exploits the great advantage of collecting entire spectra and even higher order experimental data when studying chemical samples. Behind a user friendly interface state of the art algorithms, several of which are proprietary to MultiD, are used to extract chemical information about the samples with minimum assumpt…

A new member of the HyPURITY® family introduced at Pittcon 2003, HyPURITY AQUASTAR™ columns are a new silica-based polar end-capped C18 which is designed to offer superior retention of polar compounds and increased sensitivity in 100% aqueous conditions. Product detail:A new member of the HyPURITY® family introduced at Pittcon 2003, HyPURITY AQUASTAR™ columns are a new silica-based polar end-capped C18 which is designed to off…

BioBasic AX Columns o   Improved reproducibility, efficiency and column lifetimeso   Range of stationary phases to optimize selectivityo   Powerful resolution, even on short column lengths Product detail: New BioBasic AX (weak anion exchange) columns have a polyethyleneimine (PEI) ion exchange group and a polymer coating, specifically designed to give robust and clean performance in ion exchange of acidic proteins and pep…

StarDrop is a suite of software that helps you to deliver optimally balanced, effective drugs - fast StarDrop works by evaluating complex data, which is often uncertain because of experimental variability or predictive error. In scoring this data, it brings confidence and intuitive simplicity to decision-making: guiding and validating the direction you take and which compounds you prioritise. Its instantly interactive tools t…

The CHEMICON® Alpha Integrin-Mediated Cell Adhesion Array kit is designed as a cost effective, efficient method for identification of cell surface integrins. The kit format uses 12 x 8-well removable strips in a plate frame for convenience and flexibility in designing assays. The Integrin-Mediated Cell Adhesion Array can be completed within 1-2 hours, providing a rapid, quantitative assay for the characterization of alpha inte…

The CHEMICON® Beta Integrin-Mediated Cell Adhesion Array kit is designed as a cost effective, efficient method for identification of cell surface integrins. The kit format uses 12 x 8-well removable strips in a plate frame for convenience and flexibility in designing assays. The Integrin-Mediated Cell Adhesion Array can be completed within 1-2 hours, providing a rapid, quantitative assay for the characterization of beta integr…

The CHEMICON® Alpha/Beta Integrin-Mediated Cell Adhesion Array kit is designed as a cost effective, efficient method for identification of cell surface integrins. The kit format uses 12 x 8-well removable strips in a plate frame for convenience and flexibility in designing assays. The Integrin-Mediated Cell Adhesion Array can be completed within 1-2 hours, providing a rapid, quantitative assay for the characterization of alpha…

The CHEMICON® Alpha/Beta Integrin-Mediated Cell Adhesion Array Combo Kit is designed as a cost effective, efficient method for identification of cell surface integrins. The kit format uses 12 x 8-well removable strips in a plate frame for convenience and flexibility in designing assays. The Alpha/Beta Integrin-Mediated Cell Adhesion Arrays can be completed within 1-2 hours, providing a rapid, sensitive, and quantitative assay…

The CHEMICON® ECM Cell Adhesion Array Kit (Colorimetric) provides an ECM Array microtiter plate with a colorimetric detection format, allowing for large-scale screening and quantitative comparison of multiple samples/cell lines. The kit is designed as a rapid (1-2 hours), cost effective, efficient method for characterization of cell adhesion.

The CHEMICON® ECM Cell Adhesion Array Kit (Fluorometric) provides an ECM Array microtiter plate with a homogenous fluorescence detection format, allowing for large-scale screening and quantitative comparison of multiple samples/cell lines. The kit is designed as a rapid (1-2 hours), cost effective, efficient method for characterization of cell adhesion

CHEMICON's Sure Blot® CHEMI™ Hybridization & Detection Kit is designed to provide high quality, non-radioactive detection of digoxigenin-labeled DNA probes hybridized to Sure Blot® Nylon Membrane. As an integrated hybridization and detection system, Sure Blot® CHEMI™ is quality controlled to produce high signal and low background. Comparable sensitivity to 32P is typically observed for single-copy gene detection. Sufficient re…