Identification and optimization of the chemical, series of chemicals or bio-molecule that will interact with the target using impartial, expert opinion about the best equipment, services and the latest techniques
Chemicon's cloned human CGRP1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CGRP1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CGRP1 and its ligands.
Chemicon's cloned human S1P1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant S1P1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P1 and its ligands.
EMD Millipore's S1P1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P1 interaction with its ligands. The cell line exhibits a calcium response with EC50s of 141 μM for Sphingosine 1-phosphate. The membrane preparations exhibit EC50s of 9.5 μM for Sphingosine 1-phospha…
Chemicon's cloned human PK2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant PK2 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between PK2 and its ligands.
Chemicon's cloned human EP2-expressing cell line is made in the Chem-9 host, which supports high levels of recombinant EP2 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between EP2 and its ligands.
EMD Millipore's EP2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of agonists and antagonists of EP2. The membrane preparations exhibit a Kd of 14.52 nM for [3H]-PGE2. With 7.5 nM [3H]-PGE2, 10µg/well EP2 Membrane Prep typically yields greater than 3-fold signal-to-backgr…
EMD Millipore’s cloned human Ghrelin Receptor-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant Ghrelin Receptor expression on the cell surface and contains high levels of the promiscuous G protein to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at Ghrelin Receptor.
EMD Millipore's Ghrelin Receptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of ghrelin interactions and its ligands. The membrane preparations exhibit a Kd of 0.32 nM for [125I]-ghrelin. With 0.1 nM [125I]-ghrelin, 5 μg/well Ghrelin Receptor Membrane Pre…
Chemicon's cloned human S1P4-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P4 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P4 and its ligands.
EMD Millipore's cloned human S1P5-expressing cell line is made in the Chem-5 host, which supports high levels of recombinant S1P5 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P5 and its ligands.
EMD Millipore's S1P5 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of S1P5 interactions with its ligands. The membrane preparations exhibit EC50s of 2.4 nM for S1P in a GTPγS binding assay.
EMD Millipore’s cloned human GPR92 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR92 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR92.
EMD Millipore’s cloned human GPR91 -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant GPR91 expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists at GPR91.
Chemicon's Wild-Type Chem-1 cell line is a control for Chemicon's GPCR-expressing Chem-1 calcium-optimized cell lines. The Chem-1 cell line is adherent to tissue culture-treated surfaces and contains high levels of the promiscuous G protein Galpha15 to couple many classes of GPCRs to the calcium signaling pathway.
The solid phase extraction (SPE) workstation can be used on Xiril pipetting workstations for automated nucleic acid purification based on vacuum technology. All pipetting steps of several different nucleic acid purification kits can be automated on a Xiril liquid handling workstation. Xiril’s very space saving SPE vacuum station comprises two positions, one in the front for washing steps and another in the back for the elution…
The magnetic bead separation device Magnetic PlateX can be used with a Xiril pipetting workstation for automated nucleic acid purification based on the magnetic beads technology. Speed up the process of nucleic acid purification with a magnetic beads kit using the Magnetic PlateX on a Xiril robotic workstation. All pipetting steps are taken over by the robot and the plate gripper “Plate GripX” automatically carries out the tra…
The Tube-ScanX LR is the new scanner for the automated reading of barcodes on tubes on a Xiril liquid handling robotic workstation. The barcode scanner “LR” is equipped with a laser reader for a fast record of all barcodes on tubes without interruption while reading. The laser camera with autofocus is mounted fix on the worktable. It doesn’t have to be moved whereas the tube holding racks are drawn with two of the pipetting ad…
The Plate-ScanX enables microplate identification for data tracking in an automated liquid handling process on a Xiril robotic workstation. Xiril’s plate scanner device allows reading of 1D and 2D barcodes on the side of microplates. The plate gripper of the Xiril liquid handling workstation picks up the plate and presents it in front of the barcode scanner camera.
The Thermo-ShakeX device for automated tempered shaking of microtiter plates can be mounted on a Xiril liquid handling workstation. It is capable of shaking plates at a maximum temperature of 95°C. Specific adapters for flat-bottom, round-bottom and PCR plates ensure efficient heat transfer throughout the incubation period. The Thermo-ShakeX is controlled by the Lirix software package and also permits heating or shaking only.…
The Plate-TempX low profile heating & cooling device to temper microtiter plates during an automated liquid handling process can be mounted on a Xiril pipetting workstation. The Plate-TempX station – based on Peltier technology – allows incubation of a microplate in a temperature range of +4 to +70°C. Specific adapters for flat-bottom, round-bottom and PCR plates ensure efficient temperature transfer throughout the incubation…
Speed up your automated procedures and increase the throughput of your pipetting processes with 96 channels working in parallel! Xiril’s liquid handling workstations Neon100 and Neon150 can be equipped with a 96 channel pipetting head, using air displacement technology. The pipetting range from 3-200µl allows liquid transfers into 96- and 384well micro- and deep well plates in both single- and multi-pipetting modes. The 96 cha…
SPE-10 workstation is perfect complement of fast and high-through SPE.SPE-10 workstation can process 6 samples each time. SPE-10 is modular design，Allows users handle a large number of samples by adding separate workstation. Each workstation compatible with a variety of solid phase extraction tubes，and 6 channels are independent without cross-contamination and 2 components can be collected automatically. SPE-10 can handle vari…
Who else can provide targeted solutions for your medium to high throughput applications with highest flexibility on such a small robotic workstation? The Neon technology crosses boundaries with up to 8 independent pipetting channels and its unique combination of liquid and robotic handling for all your laboratory tasks including plate handling, barcode reading, heating&shaking, extractions etc. Space saving on a small footpri…
The Transgenomic WAVE® System is among the most sensitive and accurate technologies for detection of unknown genetic mutations and single nucleotide polymorphisms (SNPs).
We supply a wide range of GC accessories to fit most common GC systems. We can provide Prep GC, sniffer systems, cryogenic trapping either with a GC or as a retrofit
