Identification and optimization of the chemical, series of chemicals or bio-molecule that will interact with the target using impartial, expert opinion about the best equipment, services and the latest techniques
GPCR Cell Lines - Validated Cell Lines for High-Throughput-Screening In cooperation with Cisbio Bioassays CCS has developed a set of recombinant cell lines stably expressing G-Protein coupled recptors (GPCRs) of high pharmacological relevance. The cell lines have been generated by stable transfection of CHO-K1 cells and subsequent clonal selection. They have been specifically validated for a read-out in homogenous time-resolv…
Cell Membranes - Custom Preparation of Cell Membranes from CCS Cell Culture Service Preparations membranes from cell which are expressing a target receptor, transporter or ion channel at a high density are a useful tool in drug research. Embedded in a membrane fragment or vesicle the proteins remain in a functional native confirmation. Ligand binding assay and functional GTP-gammaS assays can be performed with these preparati…
Thermo Scientific* LTQ FT Ultra combines the most advanced Ion Trap and Fourier Transform Ion Cyclotron Resonance technologies into a single instrument with unprecedented analytical power and versatility. Ultra-high resolution and sensitivity coupled with sub ppm mass accuracy, and MSn are universally available for the toughest applications demanding rigorous structural characterization.
Allows simpler, time saving methods for reversed phase chromatography of basic compounds: Purospher® RP-18 is a versatile HPLC column designed for the separation of problematic basic compounds with simple neutral eluents. This results in less time and cost because of simpler method optimization. Purospher® RP-18 is based upon a high purity, metal free silica. The multi-step chemical modification and deactivation of the surface…
Excellent peak symmetry with either basic or strongly acidic compounds: Purospher® RP-18 endcapped is a versatile HPLC column producing excellent peak shapes, designed for both the separation of basic compounds with simple neutral eluents and for the elution of strongly acidic compounds. Excellent separations in a shorter period of time with very good peak symmetry saves time and money. The excellent balance of Purospher® RP-1…
Purospher® STAR NH2 is a high purity aminopropyl modified stationary phase.
Purospher® STAR RP-18 endcapped is a versatile high purity reversed phase column increasing the productivity in HPLC. Purospher® STAR RP-18 endcapped provide the power to separate the most difficult of compound mixtures. With up to 150.000 N/m for 3 µm and 100.000 N/m for 5 µm particle size, Purospher® STAR RP-18 endcapped will ensure good base line separations.
SCP Science DigiSEP Blue SPE Cartridges A general purpose, single use, cation removal cartridge. DigiSEP Blue from SCP Science is a highly selective exchange cartridge is ideal for retaining transition metals in samples that contain high concentrations of potassium and sodium as in sea water. DigiSEP Blue has an aminodiacetate group that acts as a chelating agent to a variety of metallic ations in solution providing a mean t…
SCOPE, Structure-based compound optimization prioritization and evolution is an innovation from VLife to overcome challenges in lead optimization. SCOPE provides the user a way to address known problems like poor correlation between energy and activity, insensitive docking scoring functions for molecule prioritization and insufficient clues in ligand design for improvement in activity. SCOPE smartly understands the information…
Purospher® STAR RP-8 endcapped is a versatile high purity reversed phase column increasing the productivity in HPLC.Purospher® STAR RP-8 endcapped provide the power to separate the most difficult of compound mixtures. With up to 150.000 N/m for 3 µm and 100.000 N/m for 5 µm particle size, Purospher® STAR RP-8 endcapped will ensure good base line separations.
AcroPrep™ Advance filter plates are the newest edition to Pall’s filter plate family. New sealing technology and advanced tip design make these the first choice in critical sample prep applications. Aplications: Lysate Clearance DNA purification Protein purification Multiplex assays Aqueous filtration Particulate removal Size exclusion Bead-based assays Neonatal screening Flow cytometry S…
AcroPrep™ Advance Filter Plates for Ultrafiltration Provides rapid, efficient separation of biomolecules. Omega™ membrane provides high recovery and typically results in > 90% recovery of target biomolecules. New well design results in faster, more uniform filtration rates across the plate with reduced hold-up volume for maximum sample recovery Intrinsic plate and membrane properties prevent target molecules from binding to th…
eArray is a web-based application that enables you to harness the flexibility of Agilents SurePrint oligo manufacturing technology in the creation of custom microarray designs and oligo libraries. eArray, free to all registered users, allows you to create assays that are specific to your research needs. Create custom microarray designs for Gene Expression, microRNA, Model Organisms, CGH, ChiP-on-chip, and DNA Methylation.Crea…
A “Brush-type” phase with broad applicability for separation of enantiomers: Whelk-O 1 is a reliable chiral HPLC column of high solvent stability and broad applicability. Whelk-O 1 is a “brush-type” phase according to the concept of Pirkle with (3R, 4R)-4-(3,5-dinitrobenzamido)-1,2,3,4-tetrahydrophen-anthren or (3S, 4S)-4-(3,5-dinitrobenzamido)-1,2,3,4-tetrahydrophen-anthren as chiral selector with high enantoselectivity for a…
High recovery sample preparation for drug analysis and screening: LiChrolut® TSC is a selective and efficient solid phase extraction sorbent designed for clean-up of pharmaceutical products and drugs obtained from blood, plasma and urine. LiChrolut® TSC belongs to the family of the so-called “mixed-mode phases”. The combination of a reversed-phase and a cation exchange mechanism gives rise to retention of the analyte on the st…
For reproducible sample preparation: LiChrolut® CN and NH2 are medium polar phases for solid phase extraction, which produces excellent reproducibility of sample preparation. This results a combination of high chemical stability and guaranteed capacity. LiChrolut® CN and NH2 are suitable for both polar and non-polar extractions. These medium polar phases have, in addition to a short-chained propyl-spacer, a polar functional gr…
Human Cav2.2/β3/α2δ calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR®
Human Nav1.8/b3 sodium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6011. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , IonWorks Quattro®
Human a3/β4 Nicotinic Acetylcholine Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6021. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: QPatch HT™
Human GABAA (α5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR®
Human GABAA (a5β2γ2) Receptor-expressing, stable replicating cell line (CHO-K1). Cat#: CT6119. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: FLIPR®
Human Cav2.2/b3/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6159. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™ , FLIPR®
Human Cav2.1/b4/a2d calcium ion channel-expressing, stable replicating cell line (CHO-K1). Cat#: CT6196. Cryopreserved cells, 3 vials: 2x10E6 cells/vial. Platform validation: PatchXpress® , QPatch HT™
Human GABAA (α3/β2/γ2) Receptor-expressing, transiently transfected cells (HEK293). Cat#: CT7022. Cryopreserved cells, 6x10E6 cells/vial. Platform validation: PatchXpress®, FLIPR®
