Drug discovery > Lead Discovery Products & Reviews

Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems. Both novices and experts alike can quickly master MS to gain more insights from every sample.

Open new frontiers in isotope ratio mass spectrometry (IRMS) with the Thermo Scientific™ LC IsoLink™ IRMS System.

Use the new Thermo Scientific™ MAbPac™ RP columns for high-performance reversed-phase (RP) HPLC and LC/MS characterization of monoclonal antibodies (mAbs), fragments, variants, antibody drug conjugates (ADCs), PEGylated proteins, and bispecific proteins. These columns have excellent resolution, long column lifetime, and low carry-over.

Robotic liquid autosampler for GC and GCMS. Deliver high precision and high-throughput automation with simplicity.

Utilize the increased separation speed and resolution of the Thermo Scientific™ Vanquish™ UHPLC system to detect and quantify virtually any substance using the near-universal detection capabilities of Vanquish Charged Aerosol Detectors. Ideal for everyday analyses, the Thermo Scientific™ Vanquish™ Charged Aerosol Detector F offers enhanced linear dynamic range and accurate, consistent response. This detector can measure low-le…

Combine maximum injection precision and huge sample capacity. The Thermo Scientific™ Vanquish™ Split Samplers employ high-throughput performance for the highest confidence in peak identification and quantitation possible. The samplers provide fully biocompatible fluidics, unsurpassed sample dosing precision, and is optimized for ruggedness and uptime, even under the toughest system pressure of up to 1500 bar (22,000 psi) and c…

Combine maximum injection precision and huge sample capacity. The Thermo Scientific™ Vanquish™ Split Samplers employ high-throughput performance for the highest confidence in peak identification and quantitation possible. The samplers provide fully biocompatible fluidics, unsurpassed sample dosing precision, and is optimized for ruggedness and uptime, even under the toughest system pressure of up to 1500 bar (22,000 psi) and c…

Improve productivity using the Thermo Scientific™ Vanquish™ Dual Split Sampler F. Designed to support Thermo Scientific™ Vanquish™ Duo UHPLC system for Dual LC, this unique biocompatible autosampler with 1000 bar pressure, the Vanquish Dual Split Sample F combines two injection devices in one housing, resulting in two separate channels that are individually controllable (injector volume, wash cycles, etc.).

Improve productivity using the Thermo Scientific™ Vanquish™ Dual Split Sampler H. Designed to support Thermo Scientific™ Vanquish™ Duo UHPLC system for Dual LC, this unique biocompatible autosampler with 1500 bar pressure, the Vanquish Dual Split Sample F combines two injection devices in one housing, resulting in two separate channels that are individually controllable (injector volume, wash cycles, etc.).

Employ an intelligent robotic that is fully integrated into a Thermo Scientific™ Vanquish™ UHPLC system with the Vanquish Charger module. With a capacity of 8832 samples (23 well plates), the Charger module automates sample loading into the Vanquish system for extra-long unattended operation. Environmental controls ensure reliable sample protection. A barcode reader automatically inventories each plate or rack within the devic…

Reduce the size and cost of your liquid chromatography (LC) system. The Thermo Scientific™ UltiMate™ ACC-3000 Autosampler Column Compartments provides a cost-effective solution for conventional LC and UHPLC applications at up to 62MPa (9000 psi) operating pressure. It integrates an autosampler and column compartment (with optional sample thermostatting) in a single module and offers performance and flexibility that exceed mos…

Simplify off-line multidimensional and multistep liquid chromatography (LC) in analytical and micro flow rate ranges. The Thermo Scientific™ UltiMate™ Autosampler with Fraction Collector uniquely supports both sample injection, fractionation, and reinjection using two integrated switching valves. The instrument fully automates multidimensional separations, allowing columns that differ in chemistry and internal diameter to be c…

Extend your biocompatible flow path for sensitive analyses. The Thermo Scientific™ Dionex™ UltiMate™ WPS-3000TBRS Biocompatible Rapid Separation Well Plate Autosampler protects your samples from start to finish with a ceramic needle, titanium injection valve and biocompatible fingertight fittings. This UHPLC autosampler uniquely injects up to 500µL at pressures up to 15,000 psi (103.4 MPa). The in-line split-loop (or flow-thro…

Obtain maximum application flexibility including Dual LC, Tandem LC or LC-MS, and Inverse Gradient workflows using the biocompatible Thermo Scientific™ Vanquish™ Dual Pump F. This pump provides two independent ternary-solvent blending flow streams in one housing. Our built-in Thermo Scientific™ SmartFlow™ pumping technology automatically compensates for changing eluent compressibility ensuring excellent flow and gradient preci…

Enjoy the flexibility of a quaternary pump with the fast gradient performance of a binary pump. The unique Thermo Scientific™ UltiMate™ LPG-3400XRS Extended Pressure Range Quaternary Pump is an LC/MS optimized quaternary UHPLC pump offering state-of-the-art performance for high speed and ultrahigh resolution applications. The compact pump head design, with a gradient delay volume of just 200µL, supports ballistic gradients for…

Extend the capabilities of the Thermo Scientific™ Vanquish™ UHPLC platform by adding all the flexibility you can expect from a state-of-the-art quaternary solvent blending. The biocompatible Thermo Scientific™ Vanquish™ Quaternary Pump F incorporates our SmartFlow™ pumping technology, which ensures excellent flow and gradient precision, independent of eluent composition and backpressures up to 1034 bar. This gives you unrivale…

For more mobile phase flexibility in any ultrahigh speed and ultrahigh resolution application, the Thermo Scientific™ UltiMate™ HPG-3400RS Rapid Separation Binary Pump offers more solvent capability. With an unrivaled flow-pressure footprint, the RSLC pump is the most flexible binary UHPLC pump available. The UltiMate 3000 Binary RS pumps are capable of providing true ballistic gradients with excellent retention time precision…

With exceptional flow stability and adjustable delay volume, the Thermo Scientific™ UltiMate™ HPG-3200RS Rapid Separation Binary Pump excels at high-speed and high-resolution applications. An industry-leading flow/pressure footprint of 100 MPa (15,000 psi) at up to 5mL/min. and 80 MPa (11,600 psi) at 8mL/min. makes it the most flexible binary pump choice. Designed with a stainless-steel-free (biocompatible) flow path, the HPG-…

Enjoy accurate gradients and precise retention times while meeting the requirements of diverse sample types with a wide range of flow rates. The Thermo Scientific™ UltiMate™ HPG-3200SD Standard Binary Pump is ideal for analytical LC separations on standard-bore columns. With support for pressures up to 62MPa (9,000 psi, 620 bar) at flow rates of up to 10 mL/min., UltiMate 3000 SD pumps excel in standard LC applications offer a…

Developed to offer more pressure capabilities than ever before, the Thermo Scientific™ Vanquish™ Binary Pump H comes without any tradeoff on durability and robustness. From ultrafast to extremely shallow gradients at pressures up to 150 MPa, the industry-leading fourth generation Thermo Scientific™ SmartFlow™ pumping technology of the Vanquish system always provides you with unmatched retention time reproducibility and the low…

Automate labor-intensive and time-consuming beer, cider, malt, and wort testing with the Thermo Scientific™ Gallery™ Plus Beermaster Discrete Analyzer. Using discrete cell technology, the analyzer simultaneously automates the determination of analytes including beta-glucan, FAN, and SO2 from the same sample.

Employ the most widely used MS phase in gas chromatography with the 5% phenyl phase Thermo Scientific™ TraceGOLD™ TG-5MS GC Column.

Our columns represent a leap forward in performance, delivering low bleed and superior inertness. Select from our comprehensive portfolio of Thermo Scientific GC columns that meet all of your analytical needs and achieve reliable, reproducible results for your gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) applications. 

Having trouble resolving your compounds using your C18 column? The new Thermo Scientific Accucore Biphenyl LC column is your solution for: Aromatic & moderately polar analytes, Drugs of abuse, Steroids Now you can stop struggling with unresolved peaks, long run times, and poor lot-to-lot consistency. Obtain unique selectivity for aromatic and moderately polar analytes using Accucore Biphenyl LC Columns. These columns have opti…

Discover the unique Thermo Scientific™ ProPac™ Elite WCX weak cation exchange (WCX) liquid chromatography column. Designed for protein characterization including therapeutic proteins, monoclonal antibodies (mAbs), antibody drug conjugates (ADCs) and biosimilar proteins, this column offers high resolution, high efficiency separation of proteins and their charge variants. The unique column chemistry provides excellent perform…