Drug discovery > Lead Discovery Products & Reviews

Porous graphitic carbon (PGC, Hypercarb™) has unique properties as a stationary phase in high-performance liquid chromatography (HPLC). Its chemical surface properties distinguish it from more conventional LC packings such as bonded-silica gels and polymers. PGC behaves as a strongly retentive alkyl-bonded silica gel for non-polar analytes. However, its retention and selectivity behavior towards polar and structurally-related…

Ensure robust nano and capillary flow LC-MS with Thermo Scientific™ EASY-Spray™ LC Columns. The integrated column/emitter design eliminates dead volume and is temperature-controlled for maximum reliability and performance. Rigourously tested to ensure maximum quality, these columns are designed for maximum simplicity and ease-of-use.

For prep HPLC columns, one size does not fit all. Whether you need unique chemistries for difficult separations to purify your compound from impurities and side products, robust columns for longer use, or budget-friendly solutions for routine separations, our preparative column portfolio delivers. Our full range of column hardware with optional XtendedLife technology offers robust and reproducible performance along with a wide…

Develop in vitro diagnostic tests for demanding quantitative analyses leveraging the enhanced sensitivity and remarkable speed and robustness of the Thermo Scientific™ TSQ Altis™ MD Series Mass Spectrometer. The TSQ Altis MD Series mass spectrometer, a Class I medical device, offers superb analytical performance and features the maximum usability, sensitivity and robustness required for laboratory developed tests (LDTs) from c…

Prevent sample failures in bioanalytical workflows

For method development and flexibility in sample and solvent volumes

Easily create and test sample preparation methods with the Thermo Scientific™ TriPlus™ RSH Sampling Workflow Editor Software. When connected with the Thermo Scientific™ TriPlus™ RSH and TriPlus™ RSH SMART, this software enables easy programming of the autosampler to fully automate common sample handling operations as well as more complex sample preparation procedures. The visual programming approach of the software makes this…

Easy and robust mass spectrometry

EASY-Spray fully integrated HPLC column/temperature/emitter design. Glass emitter (purchased separately) delivers an exceptionally stable spray. Integrated column with temperature control provides maximum reliability and performance. A single nanoViper connection between the HPLC column and the MS ion source eliminates dead volumes. Thermo Scientific™ nanoViper™ fingertight fitting prevents overtightening and bad connections.…

Use the Thermo Scientific™ MAbPac™ Capillary Reversed Phase HPLC Column high sensitivity HPLC or LC/MS characterization of intact proteins in top-down proteomics applications where sample amount is critically limited. This versatile column can be used for peptide-mapping characterization where the capillary format balances sensitivity with throughput. 

For sensitive protein and peptide separation using nano and capillary HPLC. These emitters offer easy connection to Thermo Scientific™ MAbPac™ and Accucore™ nano and capillary columns for enhanced separation and MS detection of proteins, peptides and monoclonal antibodies (mAbs).

Efficiency transformed

Lead discovery

The Thermo Scientific™ TriPlus™ 500 Headspace Autosampler delivers reliability and robustness for testing laboratories performing volatiles analysis.

High-throughput online automated sample concentration LC-MS solution for water and beverage analysis

Automate complex and time-consuming sample preparation workflows integrated with LC-MS analysis

Employs the unique and universal Charged Aerosol Detector to consistently quantify all non-volatile and semi-volatile compounds even when no reference standard is available. Improve your lab's quantification capabilities with the Thermo Scientific Vanquish Duo HPLC and UHPLC Systems for Inverse Gradient.

Robust quantitative performance made simple

 Increase your throughput and maximize detector output using a second pump and intelligent column switching to eliminate the time required for column equilibration in gradient elutions. The Thermo Scientific Vanquish Duo HPLC and UHPLC Systems for Tandem LC or LC-MS increase sample throughput for any LC or LC-MS analysis.

Double your throughput and deepen your sample analysis using the Thermo Scientific Vanquish Duo UHPLC System for Dual LC. Features a dual split sampler and two pumps and flow paths, allowing you to run the same method or two different methods simultaneously on the same instrument, maximizing your lab productivity and return on investment.

Perform analyte pre-concentration and sample clean-up using an automated, repeatable workflow while saving your solvent usage and time compared to offline sample preparation steps. Ensure confidence in your complex sample analysis with the Thermo Scientific Vanquish Online SPE HPLC and UHPLC Systems.

Heart-Cut 2D-LC can reveal hidden impurities that co-elute with the analytes of interest by using two complementary column chemistries to gain more separation power. Increase your confidence in peak purity using the Thermo Scientific Vanquish Loop Heart-Cut 2D-LC System.  

Achieve in-depth analysis for greater confidence in peak purity and identity with the Thermo Scientific Vanquish Trap Heart-Cut 2D-LC System. This two-dimensional LC (LC-LC) system enables you to collect a single fraction of the first-dimension separation onto a trap column to pre-concentrate or achieve mobile phase compatibility for UV and MS detection.

This two-dimensional LC (LC-LC) system is an innovative, all-in-one system that uses the novel Thermo Scientific Vanquish Dual Split Sampler to enable you to switch between both system capabilities without re-plumbing. Seamlessly switch between a trap heart-cut 2D-LC system and a dual LC system using the innovative Thermo Scientific Vanquish Simple Switch 2D-LC System. 

Accelerate and automate your method development using Thermo Scientific Vanquish Method Development HPLC and UHPLC systems. These systems optimize separation conditions by testing thirteen different eluents on up to six HPLC columns. Achieve fully automated method development with ChromSwordAuto Chromeleon Connect and ChromSword AutoRobust Chromeleon Connect.