Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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TMB X-tra - Prestained

This TMB X-tra with red indicator combines all the important qualities of TMB X-tra eliminating possible mistakes during pipetting.Further the red colour may be useful in automatic analyzers giving the warning “Reagent low” when it is time for filling up the substrate. The red indicator disappears after addition of the stopping solution and will neither affect the sensitivity nor the stability of the substrate.

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ProgRes® CapturePro Software

JENOPTIK Optical Systems GmbH

The useful image capture software ProgRes® CapturePro is included in the delivery of each ProgRes® camera free of charge. Whether for simple image documentation or demanding image analysis: with merely three mouse clicks you can optimize your images – thanks to the automatic functions included in ProgRes® CapturePro software. CapturePro supports the excellent quality of ProgRes® microscope cameras and delivers optimal image…

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VeriKine™ Mouse Interferon Alpha ELISA Kit

PBL InterferonSource

Contents: One pre-coated microtiter plate and all reagents Storage Conditions: Keep at 4ºC for greatest stability. Range: 12.5 – 500 pg/ml Speed: Overnight incubation (26 hrs. 15 min.) Specificity: Mouse IFN-αA. No cross-reactivity with mouse IFN-β or IFN-γ. No cross-reactivity with human IFN-α.

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GreenScreen HC - S9 (Human Cells) and Metabolic Activation

Gentronix Ltd.

In 2008 Gentronix launches a new S9 protocol to extend the application of the GreenScreen HC assay to include the detection of genotoxic metabolites. Many pharmaceuticals only present a genotoxicity hazard after metabolism and such chemicals are called pro-mutagens or pro-genotoxins. Generally, although not exclusively, the liver is considered responsible for the “metabolic activation” (MA) of promutagens. However, none of t…

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Skyline from Aitken Scientific (Software)

Aitken Scientific Ltd Software Integration

Aitken Scientific Ltd, a leader in process control and automation, has recently become the European reseller of Comply’s process monitoring solution, Skyline. Skyline is widely applicable to anyone who needs to ensure the quality of their manufacturing processes, and the Statistical Process Control (SPC) information it provides will be of value in particular to customers focussed on GxP environments, such as the biotech and ph…

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ATPlite 1Step

Revvity

ATP luminescence assay for quantitative evaluation of proliferation and cytotoxicity of cultured mammalian cells. The 1step luciferase ATP assay format only requires one addition step, and can be used for continuous processing.

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Fraction Collectors

Kromatek

Advantec Japan, manufactures two great fraction collectors which can be used for both HPLC and other types of fraction collecting. Both units offer exceptional flexibility from the rugged x-y-z operation High quality Construction Wide choice of racks Software compatible Large sample capacity Prep option Collect by time, vol, drop or peak signal detection  CHF100SA Routine Collector A low cost Fraction Collecto…

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Atlas Software

Syrris Limited

Atlas Software is an easy to use PC based application for control and analysis of experiments. Whole systems including stirrers, circulators, RTDs, pumps, balances etc. can be configured using virtually any manufacturer’s apparatus. The “drag and drop” interface means recipes can be created, changed and saved with a click of a mouse.

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EMF-16 Precision Electrochemistry EMF Interface

Lawson Labs Inc.

The EMF16 is a high-resolution, high input impedance, data acquisition system for electrochemistry applications. It connects to a PC serial port for presentation and storage of EMF data. The bundled software is written by electrochemists for electrochemistry. It allows up to 16 channels of data to be scanned and displayed, and saved to the disk in real time.The EMF16 is built around our proven 24-bit A/D system. The DC specifi…

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Adiponectin (Rat) EIA

This kit is an enzyme-linked immunosorbent assay (ELISA) for quantitative determination of Total ADP in 10µl of rat serum, plasma or cell culture supernatants and does not cross react with Rat ADP. Format:ELISA / EIA;Sample Type:Serum, Plasma, Cell Culture;Sample Size:10 µl;Size:96 Wells; Range:0.5 - 32 ng/ml; Sensitivity:50 pg/ml; Incubation Time:3 hours 20 minutes

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PoraPak Rxn

Waters

Waters offers PoraPak™ Rxn, a family of polymer-based chromatography products for superior cleanup of synthetic reactions. PoraPak Rxn products are available in two chemistries: PoraPak Rxn CX, a strong cation-exchange sorbent and PoraPak Rxn RP, a reversed-phase sorbent.PoraPak Rxn sorbents are based on copolymers that exhibit the following properties:Hard material that does not develop increasing back pressure with flowLitt…

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3M™ Empore™ SDB-XC 47 mm Disk

3M Bioanalytical

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

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3M™ Empore™ Cation Exchange-SR 47 mm Disk

3M Bioanalytical

Cation-SR is a poly(styrenedivinylbenzene) copolymer that has been modified with sulfonic acid.  Note that Cation-SR is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  The functional group imparts selectivity for cationic analytes, such as primary, secondary and tertiary amines.

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3M™ Empore™ Anion Exchange-SR 47 mm Disk

3M Bioanalytical

3M Bioanalytical Anion-SR is a poly(styrenedivinylbenzene) copolymer that has been modified with quaternary ammonium groups.  Note that the 3M Anion-SR is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  The functional group imparts unique selectivity for anionic analytes, such as Endothall, Dalpon and haloacetic acids.

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3M™ Empore™ Oil & Grease 47 mm Disk

3M Bioanalytical

The Oil & Grease Disk was specifically designed for EPA Method 1664 (N-Hexane Extractable Materials (HEM) and Silica Gel Treated N-Hexane Extractable Material (SGT-HEM) by Extraction and Gravimetry).  EPA Method 1664 Revision A was approved for use in the United States and published in the Federal Register on May 14, 1999.  The Oil & Grease Disk incorporates C18 sorbent particles within a hydrophobic matrix. For EPA Method 166…

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3M™ Empore™ Chelating 47 mm Disk

3M Bioanalytical

Empore™ Chelating Disks provide a way to selectively remove multivalent metal cations from solutions.  This selectivity can be used to concentrate metals from a sample for analysis or to isolate and remove metal interferences from a complex organic or inorganic sample matrix.  In the latter case, the purified filtrate is ready for use.  The chelating disk has an affinity for multivalent (primarily 2+ and 3+) transition element…

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3M™ Empore™ Carbon 47 mm Disk

3M Bioanalytical

Empore Carbon Disks are designed for the extraction of volatile, highly polar, and water soluble compounds from aqueous solutions.  The Empore Carbon Disk provides all the advantages of activated carbon in a compact and thin Empore Disk.

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3M™ Empore™ C8 90 mm Disk

3M Bioanalytical

Commonly used for the solid phase extraction of analytes from complex sample matrices.  A variety of functional groups, such as octadecyl (C18) and octyl (C8) can be bonded to the silica surface to provide non polar interactions.  Each of these sorbents exhibits unique properties of retention and selectivity for a particular analyte.  The choice of which sorbent is best for a particular method will be influenced by the percent…

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3M™ Empore™ C18 90 mm Disk

3M Bioanalytical

3M bioanalytical's Empore c18 90 Disk-Commonly used for the solid phase extraction of analytes from complex sample matrices.  A variety of functional groups, such as octadecyl (C18) and octyl (C8) can be bonded to the silica surface to provide non polar interactions.  Each of these sorbents exhibits unique properties of retention and selectivity for a particular analyte.  The choice of which sorbent is best for a particular me…

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3M™ Empore™ SDB-XC 90 mm Disk

3M Bioanalytical

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

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3M™ Empore™ SDB-RPS 90 mm Disk

3M Bioanalytical

SDB-RPS is a poly(styrenedivinylbenzene) copolymer that has been modified with sulfonic acid groups to make it hydrophilic.  SDB-RPS is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  The sulfonation imparts unique selectivity for organic analytes that are polar in nature, such as drugs, drug metabolites, water-soluble pesticides and pesticide metabolites.  SDB-RPS is also u…

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3M™ Empore™ Anion Exchange-SR 90 mm Disk

3M Bioanalytical

3M Bioanalytical's Anion-SR is a poly(styrenedivinylbenzene) copolymer that has been modified with quaternary ammonium groups.  Note that the 3M Anion-SR is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  The functional group imparts unique selectivity for anionic analytes, such as Endothall, Dalpon and haloacetic acids.

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