Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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ToxReporter™ HSP70 Cell Line Starter Pack

Merck

The ToxReporter Cell Line Starter Pack 4 (Catalog # ECLSP-004) includes ToxReporter HSP70 Stimulant (Catalog # ESTM-004), Selection Agent (Catalog # ESA-001), and Assay Media Supplement (Catalog # EAMS-001). Each component is sufficient for 100 assay points. If needed, each individual component may be purchased separately. ToxReporter™ HSP70 Cell Line Starter Pack is required for use with the HSP70 ToxReporter Cell Line (Cat…

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ToxReporter™ ARE Cell Line Starter Pack

Merck

The ToxReporter Cell Line Starter Pack 8 (Catalog # ECLSP-008) includes ToxReporter ARE Stimulant (Catalog # ESTM-008), Selection Agent (Catalog # ESA-001), and Assay Media Supplement (Catalog # EAMS-001). Each component is sufficient for 100 assay points. If needed, each individual component may be purchased separately. ToxReporter Cell Line Starter Pack 8 is required for use with the ARE ToxReporter Cell Line (Catalog # EC…

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ToxReporter™ XRE Cell Line Starter Pack

Merck

One vial of ToxReporter XRE Stimulant (Catalog # ESTM-007) contains 100 µL of 100 µM 3-methylchoranthrene in 10% DMSO at 100X concentration. One vial of ToxReporter Selection Agent (Catalog # ESA-001) contains 20 mL of proprietary selection compound at 100X concentration. One vial of Assay Media Supplement (Catalog # EAMS-001) contains 1 mL of proprietary reagent at 100X concentration. ToxReporter Cell Line Starter Pack 7 is…

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ToxReporter™ HRE Cell Line Starter Pack

Merck

The ToxReporter Cell Line Starter Pack 6 (Catalog # ECLSP-006) includes ToxReporter HRE Stimulant (Catalog # ESTM-006), Selection Agent (Catalog # ESA-001), and Assay Media Supplement (Catalog # EAMS-001). Each component is sufficient for 100 assay points. If needed, each individual component may be purchased separately.   ToxReporter Cell Line Starter Pack 6 is required for use with the HRE ToxReporter Cell Line (Catalog # E…

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ToxReporter HSP70 Cell Line

Merck

This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…

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ToxReporter NFĸB Cell Line

Merck

This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…

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ToxReporter™ AP-1 Cell Line

Merck

This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…

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ToxReporter p21 Cell Line

Merck

This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…

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ToxReporter GRE Cell Line

Merck

This ToxReporter Cell Line is used in conjunction with the ToxReporter ELISA kit (cat# ETR-201K) for the measurement of ToxReporter protein secreted into cell culture media as a consequence of exposure to a potential toxin. The cell line has been designed to respond to stimuli that induce cellular stress response pathways. Examples of stressful stimuli include compounds in drug discovery and organic or inorganic molecules pote…

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ToxReporter ELISA Kit

Merck

This kit is used for the non-radioactive quantification of ToxReporter protein that is secreted into cell culture media. One kit is sufficient to measure 38 unknown samples in duplicate.

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LifeXtend™ HRP Conjugate Stabilizer/Diluent

Innova Biosciences Ltd.

LifeXtend™ conjugate stabilizer/diluent is a proprietary multi-component reagent system that stabilizes antibody-HRP conjugates both at 4°C and at ambient temperature. By using LifeXtend™ HRP stabilizer/diluent in antibody conjugation the HRP conjugate can be stabilized during use and stored as pre-diluted, ready-to-use reagents thus eliminating waste and improving consistency from experiment to experiment. LifeXtend™ shows…

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Agilent Drug Discovery Services: ADME

Experience Better Productivity and Save Resources Too RapidFire data correlates identically with traditional LC-MS/MS methods Analyses are performed at a 10+ fold increase in cycle throughput, enabling us to provide 3 day turnaround RapidFire In Vitro ADME Analysis Services increase efficiencies while preserving your lab’s assay method integrity. We use the RapidFire 360 high-throughput TOF system to analyze CYP inhibition/ind…

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Thermo Scientific Cytotoxicity 3 Multiparameter Kit

This kit enables simultaneous measurements in the same cell of six independent parameters that monitor cell health, including cell loss, nuclear size and morphological changes, mitochondrial membrane potential changes, cytochrome c release, and changes in cell permeability.

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Thermo Scientific Multiparameter Cell Death Detection Kit

The Multiparameter Cell Death Detection Kits for high-content screening (HCS) enable simultaneous quantitation of LC3B protein on autophagic vesicles, cytochrome c localization and its release from mitochrondria, cell membrane integrity and its permeability and nuclear morphology and DNA content.

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Thermo Scientific Mitotic Index Reagent Kit

The Mitotic Index HCS Reagent Kit provides high-content screening (HCS)-quality fluorescence reagents and a validated protocol for measurement of mitotic index, or the fraction of cells undergoing cell division within a population.

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Black Phenolic Cap with TFE Liner

WHEATON

Autoclavable caps that are designed to ensure the ultimate in product safety. The liners are made of a nontoxic white styrene-butadiene rubber and are faced with Teflon®, which offers excellent chemical resistance. Models available in range are the; • 13-425 Black Phenolic Cap with TFE Liner • 15-425 Black Phenolic Cap with TFE Liner • 22-400 Black Phenolic Cap with TFE Liner • 24-400 Black Phenolic Cap with TFE Liner For mor…

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Cell-based ELISA

Bio-Techne

R&D Cell-Based ELISA - Dual fluorescence detection of two biomolecules simultaneously in the context of a whole cell R&D Systems Cell-Based ELISAs permit the simultaneous detection of two proteins in the same microplate well without the need for lysate preparation. Cell-Based R and D ELISA Kits come in two formats: phospho-protein kits contain antibodies to measure both the phosphorylated and the total protein, while total p…

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Vision Life Science Spectrophotometer

Hoefer Inc. Europe

The Vision diode array spectrophotometer offers 16 predefined methodologies for nucleic acid quantification (DNA, RNA, and oligonucleotides), protein assays (BCA, Biuret, Bradford, and Lowry) and for cell culture density measurements. Additionally, the Vision can accomodate up to 90 custom protocols. The visualization of the nucleic acid scan with the full graphic display is particularly useful, especially for RNA samples wh…

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