Drug discovery > Pre-Clinical Development Products & Reviews

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Products, services, reviews and techniques used in lead molecule delivery, formulation and toxicology, using assays and animal models.

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Yeast Control™ - Cell Cycle

Sysmex Europe SE

Yeast Control™ - Cell Cycle Reagent kit for staining of yeast nuclear DNA after cell fixation by ethanol. This allows determination of total DNA and cell cycle analysis, which varies during the fermentation process. The reagent has been created specifically for selected configurations of the Sysmex CyFlow Cube and CyFlow Space flow cytometers. Kit components: 5 x 10 mg RNase A / Solution A 4 mL Solution B

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Yeast Control™ - Glycogen

Sysmex Europe SE

Yeast Control™ - Glycogen Reagent kit for measuring glycogen in yeast cells, following a cell fixation step. Glycogen content varies during the fermentation process: it is accumulated in yeast during the early exponential phase and utilized during nutrient depletion. The reagent has been created specifically for selected configurations of the Sysmex CyFlow Cube and CyFlow Space flow cytometers. Kit components: 2 x…

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Yeast Control™ - Neutral lipids

Sysmex Europe SE

Yeast Control™ - Neutral lipids Reagent kit for measuring neutral lipids in yeast. Neutral lipids serve as a storage substance and confer stress tolerance to yeast by stabilizing the membrane and protect cells against bacterial invasion. The reagent has been created specifically for selected configurations of the Sysmex CyFlow Cube and CyFlow Space flow cytometers. Kit components: 1 mL Solution A

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Yeast Control™ - Trehalose

Sysmex Europe SE

Yeast Control™ - Trehalose Reagent kit for measuring trehalose in yeast after a cell fixation step. Trehalose assists in stabilizing the yeast cell membrane during nutrient depletion and starvation, and other stresses as heat shock or ethanol exposure. It thus serves as a major stress tolerance indicator. The reagent has been created specifically for selected configurations of the Sysmex CyFlow Cube and CyFlow Space flow cy…

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Yeast Control™ - Viability

Sysmex Europe SE

Yeast Control™ - Viability Reagent kit for yeast cell counting and viability testing (differentiation between living and dead cells), both of which are relevant parameters in growing yeast cultures. The reagent has been created specifically for selected configurations of the Sysmex CyFlow Cube and CyFlow Space flow cytometers. Kit components: 1 mL Solution A 1 mL Solution B

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CyStain UV OxProtect

Sysmex Europe SE

Ready-to-use reagent for the extraction and staining of nuclei in one step. DAPI as a dye enables the determination of genome size variations and ploidy level in material or cell suspensions of various origins, including mammalian cells and plant material. CyStain UV OxProtect is especially formulated to prevent oxidation and degradation processes triggered by endogenous plant tissue oxidants.

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MassivEV™ EV Purification Column PS

FujiFilm Wako Chemicals Europe GmbH

Fujifilm Wako has developed the MassivEV™ EV Purification Column PS, which utilizes our proprietary EV isolation and purification technology known as the PS affinity method1). Used in conjunction with the specialized MassivEV™ Purification Buffer Set (Product Number: 295-96601), this system enables convenient isolation and purification of EVs, including exosomes, from liter-scale cell culture supernatants.

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GeneDirectory

Syngene

Band pattern analysis database GeneDirectory is a fast data storage and retrieval system designed for large-scale genomic fingerprinting studies, cluster analysis, VNTR analysis, genotyping and RFLP. Used in conjunction with the GeneTools gel analysis package, this combination is the most powerful and user-friendly comparison tool available today, saving you hours of repetitive work by automatically comparing thousands of…

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GeneTools

Syngene

Syngene GeneTools - Advanced 1D gel analysis Syngene GeneTools is an advanced 1D gel and 2D spot blot analysis software for use with any gel documentation system.  The Syngene GeneTools highly automated software can rapidly analyse a gel from loading an image to output of results in a matter of seconds.  With an extensive and flexible array of options you can handle a range of media including gels, plates, films and blots,…

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StarDrop 5 - Drug Discovery Software

Optibrium

StarDrop is a suite of software that helps you to deliver optimally balanced, effective drugs - fast StarDrop works by evaluating complex data, which is often uncertain because of experimental variability or predictive error. In scoring this data, it brings confidence and intuitive simplicity to decision-making: guiding and validating the direction you take and which compounds you prioritise. Its instantly interactive tools t…

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Apo-Direct TUNEL Assay Kit

Merck

The CHEMICON APO-DIRECT™ Kit is a single-step staining method for labeling DNA breaks to detect apoptotic cells by flow cytometry (Li et al. 1995). The kit contains all the reagents required for measuring apoptosis in cells including positive and negative control cells; washing, reaction, and rinsing buffers; and propidium iodide/RNase A solution for counter staining the total DNA.

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MitoLight® Mitochondrial Apoptosis Detection Kit

Merck

The MitoLight™ Apoptosis Detection Kit utilizes a lipophilic cation, termed as MitoLight™, as a mitochondrial activity marker. MitoLight™ is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. The monomer is in equilibrium with so-called J-aggregates, which are favored at higher dye concentration or higher mitochondrial membrane potential. MitoLight™ partitions differently i…

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Cell Transformation Detection Assay

Merck

CHEMICON®'s Cell Transformation Detection Assay is an anchorage-independent growth assay in soft agar, which is considered the most stringent assay for detecting malignant transformation of cells. For this assay, cells (pre-treated with carcinogens or carcinogen inhibitors) are cultured with appropriate controls in soft agar medium for 21-28 days. Following this incubation period, formed colonies can either be analyzed morphol…

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Mast Cell Degranulation Assay Kit

Merck

Chemicon's Mast Cell Degranulation Assay Kit provides a simple and convenient means for assaying tryptase activity. The assay is based on spectophotometric detection of the chromophore p-nitroaniline (pNA) after cleavage from the labeled substrate tosyl-gly-pro-lys-pNA. The free pNA can then be quantified using a spectrophotometer or a microtiter plate reader at 405 nm. A pNA Standard is provided as a comparison control.

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