Drug discovery > Target Discovery Products & Reviews

Multi-chip Liver-48 consumable plates from CN Bio enable the advanced culture of 48 miniaturized in vitro 3D liver microtissues under perfusion/ plate for comparative drug screens. Each microtissue recapitulates the functionality and microarchitecture of the human liver to accurately predict drug responses.

It can be challenging to purify sufficient high-quality protein from mammalian cells. Boost protein recovery 30-60% with an optimized covalent protein tag, called HaloTag®. This complete kit offers strong improvements in recovery, purity, cost and protein functionality over historical FLAG® and poly-His tag purification strategies.

The ONE-Glo™ + Tox Assay combines luciferase assay chemistry with a cell viability marker to better understand reporter gene expression in the context of cell health. The assay uses a two-step, addition-only process to make these measurements in a single well of a plate, negating the need to run parallel assays. The first part of the assay is a nonlytic fluorescence assay (CellTiter-Fluor™ Cell Viability Assay) that measure…

Magne™ Protein G and Magne™ Protein A Beads are magnetic affinity beads with high specificity and high capacity for purification of immunoglobulins from cell culture media, ascites and serum samples.   These paramagnetic beads are composed of iron encapsulated in macroporous cellulose with low nonspecific binding. The magnetic beads use a novel attachment chemistry to immobilize recombinant Protein G or Protein A protein…

The MethylEdge™ System provides an efficient method to rapidly perform bisulfite conversion with minimal DNA fragmentation, giving you more intact, converted DNA for downstream applications.   Start with as little as 100pg of input DNA for those precious, limited samples. Use the MethylEdge™ System with other DNA Methylation Workflow reagents to perform sensitive DNA methylation analysis on many sample types. The rapi…

The BVC family of fluid aspiration systems is a compact and easy-to-use solution for cell culture work. With its portable design as well as the option of adding a second hand controller, the BVC makes working in the lab more convenient. Built-in features like a 0.2 µm hydrophobic filter and optional quick couplings increase safety while managing potentially harmful fluids. BVCs provide the flexibility to accommodate your decon…

The AttoPhos® AP Fluorescent Substrate System provides a highly sensitive fluorescent alkaline phosphatase substrate.   The system includes AttoPhos® Substrate, AttoPhos® Buffer and Calibration Solution. AttoPhos® Substrate (2′-[2-benzothiazoyl]-6′-hydroxybenzothiazole phosphate [BBTP]) is cleaved by alkaline phosphatase to produce inorganic phosphate (Pi) and the alcohol, 2′-[2-benzothiazoyl]-6´-hydroxybenzothiazole (BB…

The MagneHis™ Protein Purification System provides a simple, rapid and reliable method for the purification of polyhistidine- or HQ-tagged, expressed proteins.   Paramagnetic precharged nickel particles (MagneHis™ Ni-Particles) are used to isolate polyhistidine- or HQ-tagged protein directly from a crude cell lysate using either a manual (requires use of a magnetic stand) or automated procedure. Using a tube format,…

The TnT® Quick Systems are convenient single-tube, coupled transcription/translation reactions for eukaryotic cell-free protein expression.   These cell-free expression systems combine the RNA Polymerase, nucleotides, salts, amino acids and Recombinant RNasin® Ribonuclease Inhibitor with the reticulocyte lysate solution to form a single TnT® Quick Master Mix. The TnT® Quick Coupled Transcription/Translation System is ava…

The Kazusa ORFeome Project was initiated to create a collection of human and mouse ORFs to enable the larger research community with a readily accessible, highly validated ORFeome. Kazusa DNA Research Institute (KDRI) is an academic Japanese research institute dedicated to genome-scale studies and the function of individual genes. KDRI is an active member of the global ORFeome Collaboration, and are experts in HUGE (Human Uni…

The Single Step (KRX) Competent Cells are designed for efficient transformation and tightly controlled protein expression.   These cells consolidate the best attributes of these two steps into one strain to evaluate protein expression in E. coli. Transformation efficiencies are greater than 108 cfu/μg, similar to other highly competent cells. The single step cells are available in single transformation size (50μl). KRX a…

For standard cloning experiments competent cells are available in two formats: high efficiency at greater than 108cfu/μg for cloning (JM109, HB101), and subcloning efficiency at greater than 107cfu/μg (HB101). JM109 cells have the additional feature of blue/white screening for recombinants. For protein expression, JM109(DE3), BL21(DE3) or KRX competent cells can be used. The Single Step (KRX) Competent Cells are designed fo…

Promega has partnered with ATCC to offer unparalleled STR testing service for human cell line authentication.   This service provides easy access to proven and comprehensive validation techniques. Promega's proprietary PowerPlex® and GenePrint® STR technology coupled with ATCC's considerable experience profiling human cell lines and extensive internal assets around STR profiling data interpretation is particularly r…

QuantiFluor® ONE system maximizes sensitivity and efficiency for dsDNA quantitation.   The QuantiFluor® ONE dsDNA System contains a fluorescent double-stranded DNA-binding dye (504nmEx/531nmEm) developed for use in an “add-and-read” format for dye and standard, making sample quantitation easy. This system enables sensitive quantitation of small amounts of double-stranded DNA (dsDNA). The QuantiFluor® ONE dsDNA Sy…

The Maxwell® Clinical Sample Concentrator (CSC) automated nucleic acid extraction system is designed for clinical laboratories needing to process multiple samples for critical downstream assays. This easy-to-use, cGMP-compliant system provides consistent, high-quality results with every run, allowing you to manage your workflow and gain efficiency. The purification methods use sample lysis and binding to paramagnetic par…

The QuantiFluor® ONE dsDNA Dye is a fluorescent double-stranded DNA-binding dye (504nmEx/531nmEm) prepared for an “add-and-read” format making sample quantitation easy. This dye enables sensitive quantitation of small amounts of double-stranded DNA (dsDNA).   The QuantiFluor® ONE dsDNA Dye is intended for use as a general purpose reagent in the US and is suitable for use by clinical laboratories as a component of la…

New line of standard and low-profile PCR plates for improved PCR efficiency.   Improve PCR efficiency with a new line of PCR plates manufactured with the best raw materials using the latest in production technologies. Standard and low profile PCR plates in clear and white are suitable for use in most thermal cyclers. These new plates combine extra-thin and uniform wall thickness with a rigid upper PP deck for easy handli…

All BRAND PCR products are available in white plastic, uniformly colored with titanium dioxide (TiO2) for optimal results when performing quantitative PCR (gPCR) with fluorescent signals.   BRAND microcentrifuge tubes fit most common rotors and may be spun up to 20,000 RCF (10,000 RCF for 0.5mL). Manufactured from virgin polypropylene, these highly translucent tubes are free from flash, air bubbles, and streaks. Caps are…

BRANDplates® inertGrade™ 96-well plates are especially suited for cell culture applications when adhesion is not desired. These plates are specifically designed for the cultivation of suspension, tumor, and stem cells, as well as other spheroid or 3-dimensional tissue culture models. They feature a surface that reduces cell adhesion and protein absorption to minimize enzyme and cellular activation. All BRANDplates® inertGra…

Innovative cell culture plates and inserts for co-culture, migration/invasion assays, 3D tissue preparation and more.   The BRANDplates Insert System, co-developed with the Fraunhofer Society, offers an innovative expansion of the BRAND cell culture product line. The new Insert system consists of 24-well standard and 6-well specialized plates and strips of hanging cell culture inserts for applications such as co-culture,…

Adaptable Microplate Solution for Custom ELISA Applications. BRANDplates® Strip Plates are especially suited for laboratories designing custom ELISA applications, or desiring increased flexibility in their ELISA application. To ensure the effective binding of a wide range of antigens or antibodies to the microplate surface, the strip plates are available in two treatment types: pureGrade™ or immunoGrade™. The pureGrade™ plate…

The BRAND Liquid Handling Station pipetting robot handles routine tasks at high speed and with the highest precision. The LHS closes the gap between electronic pipettes and highly complex, expensive pipetting robots. It is a quiet and compact instrument with a unique front door allowing it be set up in tight quarters. The instrument has 7 working positions and 5 available liquid ends with single channel volumes up to 1000uL an…

The Glucose-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of glucose in biological samples.

The Glutamate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of glutamate in biological samples.

The Glutamine/Glutamate-Glo™ Assay is a bioluminescent assay for rapid, selective and sensitive detection of glutamine and glutamate in biological samples.