Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
The Gibson Assembly ® HiFi kit uses the original Gibson Assembly ® cloning* method, which has been optimized for the seamless joining of up to five inserts into a plasmid vector, resulting in DNA constructs with reliably low error rates.
DNA variant libraries for expression of antibodies, antigens and other proteins.
The µPAC™ Flex iON Connect is a user-friendly interface to facilitate fast, reproducible and low dispersion connection of µPAC ™ nanoLC columns to Thermo Fisher Scientific Nanospray Flex™ Series ion sources. It is compatible with any type of 360µm OD electrospray emitters through one-piece fingertight fitting and it embeds a preassembled liquid junction configuration to achieve the best performance.
Synthetic single guide RNAs for efficient gene knockout & unparalleled specificity
Synthetic guide RNAs for efficient gene knockout & unparalleled specificity
Single guide RNA expressing vectors for effective and accurate gene knockout
Combine sgRNA and Cas9 nuclease expression into a single vector for simplified delivery
Our CRISPR Design Tool enables an intuitive one-stop location for guide RNA design and ordering. Utilize the design tool to order guide RNAs for targeted gene knockout or location-specific HDR-mediated genome editing.
Optimize your CRISPR-Cas9 experiments with our specific controls and primers
India Variant B.1.617 Spike Protein, as well as spike mutant proteins from the UK, South African, and Brazilian Variants. Available now!
Tailored transfection reagents for a wide variety of RNA and cells. High-efficiency delivery, low cellular toxicity, broad dynamic range
Crucial to any gene silencing or microRNA modulation experiment. RNAi controls allow accurate interpretation for reliable, reproducible results.
Tightly controlled gene silencing with the most advanced and flexible single-vector inducible shRNA.
A direct and efficient set of tools to study a gene’s function by overexpression in its native context
Tissue Solutions is a leading global provider of ethically sourced human tissue samples used in all areas of drug discovery, research and development. ISO 9001:2015 certified and twice winner of the coveted Queens Award for Enterprise, Tissue Solutions offer a single point of access for a wide range of diseased and normal tissues in fresh, frozen, and FFPE formats.
HistologiX is a leading GLP/GCP accredited Contract Research Organisation based in the UK specialising in Histology, Immunohistochemistry (IHC) and Digital Pathology services. HistologiX works with a broad range of clients from big pharma to small and medium biotech companies worldwide. Our team of scientists have in excess of 120 years combined experience and a customer retention rate of 80%.
HistologiX is a leading GLP/GCP accredited Contract Research Organisation based in the UK specialising in Histology, Immunohistochemistry (IHC) and Digital Pathology services. HistologiX works with a broad range of clients from big pharma to small and medium biotech companies worldwide. Our team of scientists have in excess of 120 years combined experience and a customer retention rate of 80%.
Reliable in vivo breath sample collection of VOCs and respiratory droplets for biomarker identification and validation. Suitable for use in a range of contexts and diverse applications including early detection, drug development and precision medicine for conditions including respiratory diseases, liver diseases and cancer. Compatible with a range of analytical systems including GC-MS analysis with Breath Biopsy Services.
Combining high resolution accurate mass mass spectrometry and world-leading breath analysis expertise to offer complete breath biomarker discovery and validation solutions. Breath Biopsy Services provide versatile Breath Biopsy sample analysis and reporting driven by GC-Orbitrap technology and supported by a rigorous quality assurance process ensuring reliable, high sensitivity VOC biomarker detection.
Exogenous volatile organic compound probes (EVOC Probes) enable targeted, non-invasive assessment of biological pathways. Probes are safe, easy to administer compounds that interact with characterised metabolic pathways with relevance to key disease areas. Using Breath Biopsy, EVOC Probes can be monitored non-invasively on breath, either alone or in parallel with biomarker discovery studies.
A targeted panel of compounds with established relevance for respiratory diseases enabling high confidence, non-invasive disease detection and monitoring. Each compound is supported by evidence from breath research studies of relevant respiratory diseases and disease processes. The panel is available as an aspect of Breath Biopsy Services and panels for other disease applications are in development.
Identify prospective biomarkers relevant to key disease processes through in vitro GC-MS analysis. Compatible with headspace sampling from cell cultures, macromolecular preparations and ex vivo samples. Driven by GC-Orbitrap high-resolution mass spectrometry and supported by a rigorous and comprehensive quality assurance process. Results are suitable for comparison with in vivo studies using Breath Biopsy Services.
