Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs. The new HTRF® SIRT1 assay, developed by Cisbio Bioassays using its patented HTRF technology, is a homogeneous method for directly measuring S…
Specially designed for use with the Cecil Adept HPLC, Q-Adept HPLC, Merit HPLC and IonQuest ion chromatography.
The Phospho-mTOR Activation Kit measures phosphorylation of mTOR, a kinase involved in the initiation of ribosome biogenesis and translation.
These stains are intense, highly photostable and match the output wavelengths of common fluorescence instrumentation. Effective image analysis in HCS cell-based assays and fluorescence microscopy requires fluorescent labeling of the entire cell. In these assays, the cellular primary object is used to identify and count individual cells and define the cell region in which the image analysis is applied. The primary object migh…
This kit enables simultaneous measurements in the same cell of six independent parameters that monitor cell health, including cell loss, nuclear size and morphological changes, mitochondrial membrane potential changes, cytochrome c release, and changes in cell permeability.
The BrdU and Ki67 Cell Proliferation HCS Reagent Kits are for simultaneous quantification of DNA replication and Ki67 proliferation marker in the same cell.
The Phospho-AKT Activation Kit measures phosphorylation of the 1, 2 and 3 isoforms of AKT, a key kinase involved in regulation of cell proliferation.
The Multiparameter Cell Death Detection Kits for high-content screening (HCS) enable simultaneous quantitation of LC3B protein on autophagic vesicles, cytochrome c localization and its release from mitochrondria, cell membrane integrity and its permeability and nuclear morphology and DNA content.
The micronucleus assay is an important component of genetic toxicology screening programs. Micronuclei arise from acentric chromosomes and lagging whole chromosomes.
The Phospho-JNK Detection Kit enables quantitation of phosphorylated Jun N-terminal kinase (phospho-JNK) expression in the nucleus.
The Autophagy & Proteasome Function: LC3B and Poly-Ubiquitin Detection Kits enable quantitation of LC3B protein on autophagic vesicles and ubiquitin on polyubiquitinated proteins.
The iNOS Activation Kits measure cytoplasmic induction of the iNOS enzyme via activation of one of the many inflammatory pathways.
The Cellomics Phospho-ATM Activation Kit contains optimized reagents for the detection and quantitation of phosphorylated ATM (Ser1981) in the nuclei.
The Mitotic Index HCS Reagent Kit provides high-content screening (HCS)-quality fluorescence reagents and a validated protocol for measurement of mitotic index, or the fraction of cells undergoing cell division within a population.
SR7500DC pushes the limits of detection and sensitivity in label-free interaction analysis.
Autoclavable caps that are designed to ensure the ultimate in product safety. The liners are made of a nontoxic white styrene-butadiene rubber and are faced with Teflon®, which offers excellent chemical resistance. Models available in range are the; • 13-425 Black Phenolic Cap with TFE Liner • 15-425 Black Phenolic Cap with TFE Liner • 22-400 Black Phenolic Cap with TFE Liner • 24-400 Black Phenolic Cap with TFE Liner For mor…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Transcription Factors and related genes reformatted onto an OpenArray plate. Kit includes: Open…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Mouse Inflammation and related genes reformatted onto an OpenArray plate. Kit includes: OpenArr…
OpenArray® Pathways are ready-to-use gene panels containing pre-validated real-time qPCR assays. The plates have over 600 assays each and are compatible with multiple sample types. Panels are currently avaliable with human or mouse genes. New panels are continually under development. Check back for updates. Real-Time qPCR assays for Mouse Transcription Factors and related genes reformatted onto an OpenArray plate. Kit includes…
The EPSON RS robots are a unique new SCARA design built to reduce cycle times and maximize work envelope usage. By designing the arm so that Joint 2 can go under Joint 1, the RS3 utilizes the entire workspace underneath the arm. There is no dead space as with other SCARA models. This allows the RS3-351 model to work on pallets as large as 494mm x 494mm. A size which normally requires a 700mm SCARA arm or larger. Speed - Ne…
Mr. M software facilitates targeted proteomics experiments by assisting during design, data collection, and result visualization. The software supports a new, more flexible targeted proteomics technique by using mass spectrometry.
The Accela PDA is optimized for the detection of high speed chromatographic separations. The short 1 cm path length, combined with the incredibly minimized cell volume of 2 μL, renders this LightPipe flowcell as the premium choice for fast separations. The extremely low level of dispersion in the LightPipe enables the flowcell to retain the excellent peak shape and chromatographic resolution from the column. Patented LightP…
The Mass Spectrometry Primer, an 82-page paperback book, covers a wide range of topics related to the most wide spread of modern mass spectrometry practices and answers some frequently asked questions about the use and capabilities of mass spectrometers. Links are also provided to articles for more in-depth reading. The first section examines who uses mass spectrometers, followed by how compounds are ionized in the source to b…
febit offers a broad variety of Geniom® Biochips useable with a Geniom RT Analyzer or febit’s Analytical Services. Customers can choose from the growing portfolio of Geniom Biochips or order Custom Geniom Biochips manufactured exactly to precise specifications. Geniom Biochips are available with validated and optimized probe design for specific applications such as: • microRNA Profiling • mRNA Profiling • HybSelect, sequence c…
The biochip from febit enables up-to-date profiling and enrichment of genes and SNPs of interest using Gene Expression Profiling, SNP-Detection, ncRNA analysis as well as targeted enrichment of genes for Next-Generation Sequencing (NGS).
