SCS110 Competent Cells
Agilent TechnologiesMost E. coli hosts contain both DNA adenine methylation (dam) and DNA cytosine methylation (dcm) genes. These genes code for proteins that methylate specific sequences when DNA is propagated, making subsequent digestion with methylation-sensitive restriction enzymes impossible. Agilent offers the SCS110 and JM110 strains, which lack both dam and dcm activity.