Products, services, reviews and techniques used in the identification and validation of the disease-causing target genes and proteins.
ESGRO Complete PLUS Clonal Grade Medium is a defined serum-free medium provided with a selective GSK3β inhibitor to enhance viability of mouse embryonic stem (ES) cells and increased maintenance of pluripotency in the absence of serum and feeder cells. This medium is intended for mouse ES cell expansion and growth at clonal density in serum-free conditions. The mouse ES cells should maintain germ line competency. Suitable fo…
The Neurite Outgrowth HCS Reagent Kit product provides a more effective solution for quantifying neurite outgrowth by combining high-content screening (HCS)-quality fluorescence reagents with a validated, automation-compatible protocol. Neurite Outgrowth Reagent Kit Features: Neuronal-specific fluorescent reagent identifies neuronal cell bodies and neurites in a heterogeneous cell population without isolation steps Val…
LifeXtend™ conjugate stabilizer/diluent is a proprietary multi-component reagent system that stabilizes antibody-HRP conjugates both at 4°C and at ambient temperature. By using LifeXtend™ HRP stabilizer/diluent in antibody conjugation the HRP conjugate can be stabilized during use and stored as pre-diluted, ready-to-use reagents thus eliminating waste and improving consistency from experiment to experiment. LifeXtend™ shows…
SIRT1 belongs to the class III family of HDACs, which are NAD+ dependent enzymes. SIRT1 modulators have been shown to play a beneficial role in treating diseases such as cancer, diabetes, metabolic disease and inflammation, making them attractive targets for the development of new drugs. The new HTRF® SIRT1 assay, developed by Cisbio Bioassays using its patented HTRF technology, is a homogeneous method for directly measuring S…
Specially designed for use with the Cecil Adept HPLC, Q-Adept HPLC, Merit HPLC and IonQuest ion chromatography.
The Phospho-mTOR Activation Kit measures phosphorylation of mTOR, a kinase involved in the initiation of ribosome biogenesis and translation.
These stains are intense, highly photostable and match the output wavelengths of common fluorescence instrumentation. Effective image analysis in HCS cell-based assays and fluorescence microscopy requires fluorescent labeling of the entire cell. In these assays, the cellular primary object is used to identify and count individual cells and define the cell region in which the image analysis is applied. The primary object migh…
This kit enables simultaneous measurements in the same cell of six independent parameters that monitor cell health, including cell loss, nuclear size and morphological changes, mitochondrial membrane potential changes, cytochrome c release, and changes in cell permeability.
The BrdU and Ki67 Cell Proliferation HCS Reagent Kits are for simultaneous quantification of DNA replication and Ki67 proliferation marker in the same cell.
The Phospho-AKT Activation Kit measures phosphorylation of the 1, 2 and 3 isoforms of AKT, a key kinase involved in regulation of cell proliferation.
