RNA Polymerase II Toolbox
Chromotek GmbHRNA polymerase II features a large carboxyl-terminal repeat domain (CTD) that consists of the consensus heptapeptide Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7. Differential phosphorylation in this CTD orchestrates accessibility for various co-factors of the transcription complex. Using the phosphorylation specific antibodies it is now possible to determine specific phosphorylation states. In addition to phosphorylation specific antib…