High-Throughput Screening Products & Reviews

High-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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StarDrop 5 - Drug Discovery Software

Optibrium

StarDrop is a suite of software that helps you to deliver optimally balanced, effective drugs - fast StarDrop works by evaluating complex data, which is often uncertain because of experimental variability or predictive error. In scoring this data, it brings confidence and intuitive simplicity to decision-making: guiding and validating the direction you take and which compounds you prioritise. Its instantly interactive tools t…

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PrecisION™ Membrane Preparation Recombinant hERG Potassium Ion Channel

Merck

EMD Millipore's hERG membrane preparations are crude membrane preparations made from HEK293 stable recombinant cell lines, which are ideal HTS tools for screening antagonists against the hERG channel. The membrane preparations exhibit a Kd of 5.2 nM for [3H]-Astemizole. With 10 μg/well hERG Membrane Prep and 3.0 nM [3H]-Astemizole, a greater than 4-fold signal-to-background ratio was obtained.

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cAMP HTS Immunoassay Kit, 384 well (Chemiluminescent)

Merck

EMD Millipore's cAMP HTS immunoassay kit, 384 well is a competitive immunoassay for quantitative chemiluminescence-based detection of cAMP in cell lysates and supernatants, which has been optimized for use in high throughput screening applications. The kit provides two ready to use 384 well pre-coated assay microplates and all reagents required to perform the assay.

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ChemiSCREEN™ Chem-1 Membrane Preparation, Null Control

Merck

Chem-1 cells are an adherent cell line endogenously overexpressing Galpha15 that is used as a host for Chemicon's ChemiScreen™ GPCR Membrane Preparations. Chemicon's ChemiScreen™ Wild-Type Chem-1 Membrane Preparations are ideal controls for validation of radioligand binding assays employing ChemiScreen™ GPCR Membrane Preparations in the Chem-1 host cell line.

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ChemiSCREEN™ Human Recombinant CXCR1 Chemokine Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human CXCR1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR1 and its ligands.

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ChemiSCREEN™ Membrane Preparation Recombinant Human CXCR1 Chemokine Receptor

Merck

EMD Millipore's CXCR1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of CXCR1 interaction with IL-8. The membrane preparations exhibit a Kd of 0.2 nM for [125I]-IL-8. With 5 μg/well CXCR1 Membrane Prep and 0.1 nM [125I]-IL-8, a greater than 5-fold signal-to-…

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ChemiSCREEN™ CXCR2 Calcium-Optimized FLIPR Cell Line

Merck

Chemicon's cloned human CXCR2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR2 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR2 and its ligands.

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ChemiScreen™ CXCR2 Membrane Preparation

Merck

Chemicon's CXCR2 Membrane Preps are ideal tools for screening for antagonists of interactions between CXCR2 and its ligands. Radiolabeled IL-8 binds to the CXCR2 membranes with a Kd of 0.075 nM. With 0.1 nM 125I-labeled IL-8, a 5-fold window of specific binding is obtained.

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ChemiSCREEN™ Human Recombinant CXCR3 Chemokine Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon’s cloned human CXCR3-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CXCR3 expression on the cell surface and contains high levels of the promiscuous G protein G16 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CXCR3 and its ligands.

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