Biomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :
Exogenous volatile organic compound probes (EVOC Probes) enable targeted, non-invasive assessment of biological pathways. Probes are safe, easy to administer compounds that interact with characterised metabolic pathways with relevance to key disease areas. Using Breath Biopsy, EVOC Probes can be monitored non-invasively on breath, either alone or in parallel with biomarker discovery studies.
A targeted panel of compounds with established relevance for respiratory diseases enabling high confidence, non-invasive disease detection and monitoring. Each compound is supported by evidence from breath research studies of relevant respiratory diseases and disease processes. The panel is available as an aspect of Breath Biopsy Services and panels for other disease applications are in development.
Identify prospective biomarkers relevant to key disease processes through in vitro GC-MS analysis. Compatible with headspace sampling from cell cultures, macromolecular preparations and ex vivo samples. Driven by GC-Orbitrap high-resolution mass spectrometry and supported by a rigorous and comprehensive quality assurance process. Results are suitable for comparison with in vivo studies using Breath Biopsy Services.
Consumable components of the Breath Biopsy system, required for robust breath sample collection using the ReCIVA Breath Sampler as part of the Breath Biopsy Collection Station. One Kit per sample.
Reliable and reproducible, non-invasive Breath Biopsy sample collection for high-accuracy analysis of human breath. ReCIVA provides high quality sample collection alongside ease-of-use and patient safety and comfort. Samples are easy to store and transport and can be analysed using a wide range of techniques. We recommend processing Breath Biopsy samples using high-accuracy GC-MS, available through Breath Biopsy Services.
A versatile and easy to use analyzer for the detection of biomarkers in clinical samples using field asymmetric ion mobility spectrometry (FAIMS). Rapid, portable, sensitive and selective, Lonestar has wide-ranging applications for the detection and quantification of volatile organic compounds (VOCs) from a variety of sample types including feces, urine and breath.
Introducing LabSat® Research by Lunaphore, a flexible IHC/IF staining solution for the research lab
Our LC-MS capabilities offer a flexible service from discovery, through to regulated GLP preclinical and GCP clinical studies.
From picolitre to microliter, contact and non-contact dispensing technology combined in one highly automated production environment. The iZERO is M2-Automation`s ultra-fast, high-precision and fully flexible production line.
Protein Biomarker Testing and Custom Assay Development Services
Glial Fibrillary Acidic Protein (GFAP) is a class-III intermediate filament majorly expressed in astrocytic glial cells in the central nervous system. Astrocytes play a variety of key roles in supporting, guiding, nurturing, and signaling neuronal architecture and activity. Monomeric GFAP is about 55kD. It is capable of forming both homodimers and heterodimers; GFAP can polymerize with other type III proteins or with neurofila…
The Simoa Human Neurology 4-Plex E (N4PE) assay simultaneously measures four biomarkers in EDTA plasma and CSF. The targets are Abeta 40 (Aβ40), Abeta 42 (Aβ42), Glial Fibrillary Acidic Protein (GFAP™), and Neurofilament light (Nf-L). Each biomarker has been demonstrated to have significance for the investigation of neurodegeneration and brain injury, and to have utility for monitoring effectiveness of drug discovery and devel…
The Simoa Human Neurology 2-Plex assay (N2PB) measures two important neurology biomarkers in both cerebrospinal fluid (CSF) and blood. The two targets are neurofilament light (Nf-L) and glial fibrillary acidic protein (GFAP™), which have been studied as indicators of traumatic brain injury (TBI) severity. N2PB has been developed as a 2-Plex version of the Neurology 4-Plex B assay (N4PB). *Banyan GFAP™ is a registered tradem…
The Luminex xMAP INTELLIFLEX is an advanced platform for accurate protein measurement in a compact instrument. With an option for a second reporter laser, it allows detection of two parameters on a single bead, maximizing data points and sample processing. Designed for high throughput, it is the most advanced Luminex instrument. Compatible with R&D Systems Luminex assays and Quantist Analysis Software.
The FLEXMAP 3D is a versatile and powerful multiplexing platform from Luminex. Fast read time, compatibility with 96- and 384-well plates, and ease of integration with front-end automation systems make the FLEXMAP 3D a reliable choice for high-throughput applications. Compatible with R&D Systems Luminex assays and Quantist Analysis Software.
The Luminex 200 utilizes principles of flow cytometry and is the gold standard for basic multiplexing protein needs. Simultaneously multiplex up to 100 analytes in a single microplate well. Delivers fast and cost-effective results on many assay formats. The Compatible with all R&D Systems Luminex assays and the Quantist Analysis Software.
Millipore now proudly offers the MILLIPLEX® MAP Human Cancer Biomarker Panel. The Cancer Biomarker Panel includes both a Five-Plex assay, which simultaneously measures five serum biomarkers, Macrophage Migration Inhibitory Factor (MIF), Prolactin, CA-125, Leptin and Osteopontin (OPN), and a Single Plex IGF-II assay. The combination of the six serum biomarkers that discriminate between disease-free and ovarian cancer patien…
STN is an online database service that provides global access to published research, journal literature, patents, structures, sequences, properties, and other data.
The mTRAQ™ Reagents are duplex amine-specific, stable isotope labeled reagents designed for high confidence protein and peptide biomarker verification using MRM analysis on the QTRAP® system and the triple quadrupole mass spectrometers. * Duplex mass difference tags (Non-Isobaric Amine Tags) * Established chemistry with > 95% labeling efficiency * High selectivity MRM based relative quantitation of proteins/peptides/PTMs * Sup…
Innova Biosciences – Antibody Conjugation Service Bio-conjugates can be challenging to optimise and time consuming to produce: 1. Too much conjugation may result in the target protein becoming inactive and insoluble. 2. Too little conjugation can result in weak signals. 3. Our competitors require milligrams of your precious material and have a 2 week process time. Fast & FAb™ Antibody Conjugation Service – Innova Biosciences t…
R&D TNF-alpha / TNFSF1A - Recombinant Human Protein Tumor necrosis factor alpha (TNF-alpha), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. Specifications and Use for R&D TNF-alphaSource of R&D TNF• A DNA sequence encoding the mature human TNF-α protein sequence (Accession…
