Process chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.
T-box transcription factor (TBX21) is a member of the T-box protein family, which shares a common DNA-binding domain. TBX21 plays a critical role in Th1 cell differentiation through stimulation of IFN γ. Due to a hypersensitive immune system, the Tbx21 (-/-) rat model is useful for studies of acute and chronic human asthma, Crohn’s disease, colitis, cancer metastasis, autoimmune disorders and inflammation.Tbx21 (T-beta) Knock…
This model contains a bi-allelic deletion within the peroxisome proliferator-activated receptor alpha gene (Ppara). Ppara Knockout Rat Characteristics: Homozygous Knockouts exhibit complete loss of protein via Western blot Background Strain: Sprague-Dawley Research Applications: Lipid metabolism Diabetes Obesity Cell proliferation Wound healing Inflammation/Autoimmune disorders
Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Pink1 (PTEN-induced putative kinase 1) gene, encoding for a serine/threonine protein kinase. Mutations in Pink1 are implicated in early-onset Parkinson’s disease. Pink1 knockout rats show both motor impairments and dopaminergic cell loss, making this a useful model of Parkinson’s disease.Pink1 (Park6) Knockout Rat Characterist…
This model contains a biallelic deletion within the Disc1 (disrupted in schizophrenia 1) gene, encoding the DISC1 protein. A translocation disrupting Disc1 was discovered to co-segregate with major psychiatric illness in a Scottish family. This model is useful in the study of schizophrenia.Disc1 Knockout Rat Characteristics: Disc1 is involved in neuronal growth and cortical development The protein also regulates the pro…
This model contains a biallelic deletion of the neuroligin 3 gene (Nlgn3). Mutations in Nlgn3 have been linked with autism and Asperger’s syndrome. This model is useful for understanding the role of neuroligins in the development of autism spectrum disorders.Neuroligin 3 (Nlgn3) Knockout Rat Characteristics: This model was created in collaboration with Autism Speaks and is currently undergoing phenotypic characterization…
This model expresses cre-recombinase under the control of the endogenous tyrosine hydroxylase promoter enabling specific expression in dopaminergic neurons. This model possesses a targeted insertion of (IRES)-cre immediately after the translational stop in the open reading frame of Th. The TH-Cre rat is useful for applications requiring tissue specific expression, including optogenetics and breeding with transgenic floxed lin…
Colony Expansion and Custom Breeding Services SAGE® Labs offers continued support for your custom model generation needs. Whether it’s breeding a small cohort of homozygous knockouts for characterization or expansion for regular cohort delivery, our expert staff will work with you to determine the best breeding plan to meet your research goals.Features: Specific pathogen-free facility Comprehensive health monitoring pro…
Developed from a line of Crl:CD(SD) rats. Two lines were developed from this outbred colony, the OP-CD (Obese Prone) and OR-CD (Obese Resistant). This model becomes obese when fed high-fat diets. Obesity develops despite having a fully functioning leptin receptor. The control for this model is the Crl:OR(CD). Model Properties: Coat Color: White (albino) Ideal For: obesity, metabolic syndrome Strain Code: 463
PCSK9 mice were created utilizing a full-length human PSK9 cDNA with a C-terminal V5 tag expressed under the transcriptional control of a composite human albumin promoter containing a 235 bp SV40 enhancer and a 213 bp albumin promoter element. A chimeric intron was inserted between the promoter and PCSK 9 cDNA to enhance expression. The expression cassette was flanked by a 1.2 kb insulator sequence from the chicken beta-globu…
Okamoto, Kyoto School of Medicine, 1963, from outbred Wistar Kyoto male with marked elevation of blood pressure mated to female with slightly elevated blood pressure. Brother x sister mating with continued selection for spontaneous hypertension was then started. To NIH in 1966 from Okamoto at F13. To Charles River from NIH in 1973 at F32.Model Properties: Coat Color: White (albino) MHC Haplotype: RT1k Ideal For: genet…
