HTS Libraries Products & Reviews

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ChemiSCREEN™ CCR9 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human CCR9-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant CCR9 expression on the cell surface and contains high levels of the promiscuous Galpha15 protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between CCR9 and its ligands.

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ChemiSCREEN™ CCR9 Membrane Preparation

Merck

Chemicon's CCR9 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of CCR9 interactions with its ligands. The membrane preparations exhibit an EC50 of 8 nM for TECK/CCL25 in a GTPgammaS binding assay.

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ChemiSCREEN™ Membrane Preparation Recombinant Human D2 Dopamine Receptor

Merck

EMD Millipore's D2 dopamine membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of D2 dopamine receptor interactions with its ligand. The membrane preparations exhibit a Kd of 0.51nM for [125I]-Iodospiperone. With 5.0 ug/well D2 Dopamine Membrane Prep and 0.1nM […

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ChemiScreen™ VPAC1 Membrane Preparation

Merck

Chemicon's VPAC1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of VPAC1 interactions with VIP. The membrane preparations exhibit a Kd of 1.2 nM for [125I]-VIP. With 2.5 μg/well VPAC1 Membrane Prep and 0.4 nM [125I]-VIP, a greater than 5-fold signal-to-backg…

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ChemiScreen™ A1 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human A1-expressing cell line is made in the Chem-3 host, which supports high levels of recombinant A1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between A1 and its ligands.

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ChemiScreen™ A1 Membrane Preparation

Merck

Chemicon's A1 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of A1 interactions with its ligands. The membrane preparations exhibit a Kd of 1.2 nM for [3H]-Cyclopentyl-1, 3-dipropylxanthine, 8-[dipropyl-2, 3-3H (N)]. With 5mg/well A1 Membrane Prep and 20nM […

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ChemiScreen™ CXCR6 Membrane Preparation

Merck

Chemicon's CXCR6 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of CXCR6 interactions with its ligands. The membrane preparations exhibit a Kd of 0.6 nM for [125I]-CXCL16. With 2.5 or 10 μg/well CXCR6 Membrane Prep and 0.5 nM [125I]-CXCL16, greater than 4-fo…

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ChemiScreen™ PRP Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human PRP-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant PRP expression on the cell surface and contains high levels of the promiscuous G protein G-15 to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between PRP and its ligands.

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ChemiScreen™ V1A Vasopressin Membrane Preparation

Merck

Chemicon's V1A membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of V1A interactions with its ligands. The membrane preparations exhibit a Kd of 55 pM for [125I]-vasopressin antagonist ([125I]-phenylacetyl-D-Tyr(Me)-Phe-Gln-Asn-Arg -Pro-Arg-Tyr-NH2). With 10 µg/well V1A Membr…

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ChemiScreen™ AT1 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human AT1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant AT1 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between AT1 and its ligands.

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ChemiSCREEN™ Human Y2 Neuropeptide Receptor Membrane Preparation

Merck

Chemicon's Y2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of Y2 interactions and its ligands. The membrane preparations exhibit a Kd of 1.28 nM for [125I]-human PYY. With 0.5 nM [125I]-human PYY, 5 or 10µg/well Y2 Membrane Prep yields greater than 10-fold…

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ChemiScreen™ ChemR23 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human ChemR23-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant ChemR23 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between ChemR23 and its ligands.

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ChemiScreen™ β2 Adrenoceptor Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human β2-expressing cell line is made in the Chem-2 host, which supports high levels of recombinant β2 expression on the cell surface and contains high levels of the promiscuous G protein Gα16 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists and antagonists of β2.

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ChemiScreen™ Recombinant Human β2 Adrenoceptor

Merck

Chemicon's β2 adrenoceptor membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of β2 adrenoceptor interactions with (-)Iodocyanopindolol (ICYP). The membrane preparations exhibit a Kd of 0.51 nM for [125I]-(-)ICYP. With 5 µg/well β2 Adrenoceptor Membrane Prep and…

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ChemiScreen™ PK1 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human PK1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant PK1 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to enhance coupling of the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between PK1 and its ligands.

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ChemiScreen™ S1P2 Calcium-Optimized FLIPR Cell Lines

Merck

Chemicon's cloned human S1P2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant S1P2 expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between S1P2 and its ligands

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ChemiSCREEN™ Human VPAC2 VIP Receptor Membrane Preparation

Merck

Chemicon's VPAC2 membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of VPAC2 interactions with PACAP. The membrane preparations exhibit a Kd of 0.9 nM for [125I]-PACAP27. With 5 µg/well VPAC2 Membrane Prep and 0.5 nM [125I]-PACAP27, a greater than 15-fold signal…

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ChemiSCREEN™ Human Recombinant 5-HT2A Serotonin Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human 5-HT2A -expressing cell line is made in the Chem-1 host, which supports high levels of recombinant 5-HT2A expression on the cell surface and contains high levels of the promiscuous G protein Galpha15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between 5-HT2A and its ligands.

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ChemiScreen™ Recombinant HumanMembrane Preparation α1A Adrenergic Receptor

Merck

Chemicon's α1A membrane preparations are crude membrane preparations made from our proprietary stable recombinant cell lines to ensure high-level of GPCR surface expression; thus, they are ideal HTS tools for screening of antagonists of α1A interactions with prazosin. The membrane preparations exhibit a Kd of 1.34 nM for [3H]-prazosin. With 5 µg/well α1A Membrane Prep and 1 nM [3H]-prazosin, a greater than 7-fold signal-to-bac…

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ChemiScreen™ LPA1 Lysophopholipid Receptor Calcium-Optimized Stable Cell Line

Merck

Chemicon's cloned human LPA1-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant LPA1 expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between LPA1 and its ligands.

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