A Comparison of the Kinetex C18 Core-Shell Column’s Performance in Comparison to a Conventionally Fully Porous UHPLC Column

This application note investigates the Kinetex 2.6 µm PS C18 HPLC/UHPLC column’s improved chromatographic performance and unique multi-interaction selectivity when applied to a screen of 36 tricyclic antidepressants (TCA). Because the Kinetex 2.6 µm core-shell (superficially porous) particle morphology provides ultra-high column efficiency on any HPLC or UHPLC system, the investigation also included a comparison to a conventual fully porous 1.9 µm UHPLC column.