A comprehensive workflow for PFAS analysis in wastewater with extended EPA draft method 1633 list

In this application note, Agilent addresses the challenge of detecting trace levels of per- and polyfluoroalkyl substances (PFAS) in wastewater due to their stability and bioaccumulation potential. Agilent presents a comprehensive workflow based on EPA draft Method 1633, involving solid-phase extraction (SPE) and clean-up steps, followed by LC-MS/MS analysis and automated reporting. This methodology provides a reliable and robust solution for targeted PFAS analysis in complex matrices, overcoming interference from environmental matrices and background contaminants.