A kinase inhibitor phenotypic screen using a novel multiplex T cell activation assay

In recent years, there has been renewed interest in using phenotypic screens for drug discovery. This screening methodology does not require a specific drug target or knowledge of its role in the pathology of disease, but uses a specific, relevant biological model or signaling pathway to identify appropriate targets. This application note demonstrates the insight provided by the use of the Intellicyt platform for phenotypic screening of small molecules affecting T cell activation.