A Novel Approach for Gentle Sorting of Adult Neural Stem Cells from Wild Type Mouse Brain

Neural stem cells (NSCs) in the adult subventricular zone (SVZ) and the dentate gyrus have the capacity to self-renew and generate new neural cells throughout their lifetime. Their ability to react to brain injury by generating new neurons makes them a valuable cell source for endogenous repair in the adult brain. NSCs are a very rare and sensitive cell population, and a complex marker combination is necessary to distinguish them from other cells. Therefore, their purification still poses a great challenge.