A Novel Microliver Production Technology for High-Throughput Livertox Screening Systems

Primary hepatocytes are commonly used to study drug metabolism, enzyme induction and compound hepatoxicity. To mimic a more natural environment, InSphero developed a new scaffold-free, organotypic production technology for 3-dimensional hepatic microtissues. This study demonstrates the validity and suitability of the Gravity^Plus hanging drop platform for liver microtissue culture, offering a highly functional and reliable in vitro toxicology testing system which can be easily implemented into standard lab automation processes.