AAV analytics with mass photometry

Mass photometry is an innovative technology that analyzes biomolecules, including adeno-associated viruses (AAVs), at the single-particle level, in their native state and without the need for labels. In this application note, Refeyn shows that mass photometry is an ideal analytical technology for AAV research, development and manufacturing. In just minutes, a mass photometer can precisely measure the empty/full capsid ratio for AAVs of any serotype. It requires only very small sample volumes and concentrations, and minimal sample preparation.