Accurate and Repeatable Measurement of Fine Crystalline APIs using Laser Diffraction

Solid active pharmaceutical ingredients (APIs) are best to be measured in their original dry state in order to receive a reliable characterization of the particle size distribution. To achieve meaningful results from laser diffraction analysis, dosing and dispersion of the sample is performed by the dry dispersion system RODOS & VIBRI. Dispersed particles are being fed to the measuring zone of the modular laser diffraction sensor HELOS as a free aerosol jet. The particle size spectrum is determined with the highest degree of accuracy, repeatability and reproducibility.