Achieving Secure Sealing and Instrument Handling in 9 mm Screw Thread Chromatography Vials

This technical note reviews the design features of Advanced Vial Closure System (AVCS) and provides data to support how AVCS eliminates under/over compression of vial seals while improving robotic autosampler pick-up of vials by assuring a more level and centered vial closure orientation. A study of the effects of the typical operator response to evaporative sample loss and septum dislodging during the use of standard 9 mm chromatography vials and closures was conducted.