AI-enabled automated compound screening for toxicity effects using healthy human intestinal organoids

Discover how the CellXpress.ai^® Automated Cell Culture System and the ImageXpress^® HCS.ai High-Content Screening System deliver a fully automated, AI-powered workflow for compound toxicity screening using healthy human intestinal organoids.

This application note highlights a scalable solution that integrates automated organoid culture, compound dosing, and high-content imaging with machine learning–driven phenotypic analysis. By combining deep learning segmentation (SINAP) and phenotypic classification (Phenoglyphs™) found in IN Carta® Image Analysis Software, the system accurately distinguishes between cytotoxic, cytostatic, and viable organoid responses.