An Information System Enabling the Organization and Automatic Annotation of Proteomic Experiments with User-Specific Proteins

Researchers studying engineered proteins or other proteins not defined in public sequence repositories wish to quantitatively analyze and annotate their results in the same manner as with publicly known sequences. Thermo Scientific™ ProteinCenter™ software provides an annotation framework allowing the interpretation of proteomics results in a biological context using established protein databases and annotated sequence variants, including proteoforms. To demonstrate the new functionalities of ProteinCenter we show a differential analysis from an interactomics study using a proximity-dependent strategy where a point-mutation is expected to interfere with biologically relevant interactions.