An Ion Mobility-Enabled Data Independent Multi-Omics Approach to Quantitatively Characterize Urine from Children Diagnosed With Idiopathic Nephrotic Syndrome

The pathogenesis of Idiopathic Nephrotic Syndrome (INS) is still unknown and therapy options are confined to immune modulation. A variety of methods for diagnostic and treatment purposes are available for patients; however the lack of understanding of the pathogenic mechanism leads to poor treatment. This study describes a multi-omic approach to reveal new pathogenic molecular factors by implementing HDMSE which provides both quantitative and qualitative information.