Analysis and quality control of lipid-based formulations, such as mRNA vaccines, by HPTLC

Lipid-based formulations, such as liposomes or lipid nanoparticles, protect fragile molecules like mRNA from being digested or chopped up before reaching their target. In this application note, CAMAG presents a high-performance thin-layer chromatography (HPTLC) separation and detection method for identity testing, purity testing, and quality control of lipid-based formulations used for drug solubilization and pharmaceutical formulations, such as mRNA vaccines.