Analysis of an IgG1 Sample by Microfluidic Modulation Spectroscopy (MMS)

Microfluidic Modulation Spectrometry (MMS) is a novel protein characterization technique that combines a microfluidic cell and a tunable mid-IR quantum cascade laser source to assess the comparability, similarity, quantitation linearity, aggregation, and denaturation of proteins by analyzing the absorbance spectra and the high order structure (HOS). To evaluate the data quality and performance of MMS, an IgG1 sample was analyzed at different concentrations ranging from 0.1 mg/mL to 12.3 mg/mL using a RedShiftBio AQS³pro pre-production instrument.