Analysis of NIST® Gold Nanoparticles Reference Materials Using the NexION 300 ICP-MS in Single Particle Mode

This application note explores the capability of modern ICP-MS to measure the key characteristics of metal manufactured nanoparticles. ICP-MS is rapidly becoming the elemental measurement technique of choice for assessing the manufacturing and environmental life cycle of engineered nanoparticles. In Standard mode, an ICP-MS provides accurate composition and concentration measurements. In Single Particle mode (SP-ICP-MS), it allows the differentiation between ionic and particulate signals, measures particle sizes (if shape is known), and explores agglomeration and size distribution.