Analysis of Per-and Polyfluoroalkyl Substances (PFAS) Specified in EPA M537.1 Using the Triple Quadrupole LCMS-8045

The EPA recently updated Method 537 to 537.1 to incorporate the replacement PFAS introduced into the market after PFOA and PFOS were phased out in the US market. This application note demonstrates that analysis for all analytes listed in EPA 537.1 can be performed on the LCMS-8045, meeting the Quality Assurance and Quality Control criteria specified in the method. Recoveries were greater than 80% for all compounds, with surrogate recoveries within 10% of the true value. Method Detection Limits (MDL) were below 2 ppt for all the target analytes.