Analysis of Tyrosine Kinase Signaling in Human Cancer by Stable Isotope Labeling with Heavy Amino Acids in Mouse Xenografts Utilizing Mouse Express® Lysine 13C6 Mouse Feed

Tyrosine kinases (TK) play important roles in the induction of cell growth, survival and migration. In this note, a novel proteomic approach to label tumors in nude mice xenografted with human cancer cells using Mouse Express^® L-Lysine (13C6, 99%) Mouse Feed (MF-LYS-C) is described.