Analysis of USP <467> residual solvents of Class 1, Class 2, and Class 3 using the Agilent 8890 GC/ FID /5977B MSD System

An Agilent 8890 Gas Chromatograph (GC) configured with a flame ionization detector (FID) and a mass spectrometric detector (MSD) was used for the analysis of USP <467> residual solvents of Class 1, Class 2, and Class 3. There were 52 compounds with low boiling points introduced by an Agilent 7697A headspace sampler onto a DB-624 column, while 10 compounds with relatively high boiling points were introduced by the automatic liquid sampler onto a DB-WAX column. A purged two-way capillary flow technology (CFT) device was used to split the sample 1:1 onto FID and MSD.