Analysis of xylazine, opioids, and other common adulterants in blood and urine by SPE and LC-MS/MS

In this application note, UCT, Inc. outlines a method for simultaneously analyzing fentanyl, its analogs, xylazine, and other common adulterants using solid-phase extraction (SPE) and LC-MS/MS. Xylazine, a veterinary sedative, is increasingly used as an adulterant, particularly in fentanyl-containing substances. This combination, known as 'Tranq', poses serious risks, including unconsciousness and heightened addiction, potentially leading to fatal overdoses.