Antibody-Drug Conjugates (ADCs): The magic bullets for treatment

In recent years, Antibody-Drug Conjugates (ADCs) may serve as a novel therapeutic modality for many cancer patients. Indeed, three key elements define an ADC: the antibody directed against a specific tumor antigen, the cytotoxin/payload, and the cleavable/uncleavable linker connecting the payload to the antibody. Specific target recognition and effective toxin make ADCs veritable "magic bullet". These 'magic bullets' deliver treatment that is both highly targeted and highly potent, seeking out and attacking cancerous cells throughout the body, while avoiding harm to healthy cells. Reasonable selection of targets, antibody, linker, payload and their rational combinations are crucial for an effective treatment. In this application note, ACROBiosystems outline the benefits of ADCs as an effective treatment option.