Application of GC High Resolution Time-of-Flight Mass Spectrometry to Mouse Liver Metabolomic Analyses

In this note GC High Resolution Time-of-Flight Mass Spectrometer is applied to the identification and differential analysis of metabolites extracted from diseased livers of mice exposed to alcohol with and without fatty diets. The aim is to study the role of alcohol and PCBs on mice fed with an unsaturated fat diet, it is therefore important to identify metabolites that have significant abundance changes in mice liver induced by alcohol.