Automated Plasma Protein Precipitation and Filtration for LC/MS Sample Preparation with the MICROLAB® STAR

Plasma samples are commonly analyzed by LC/MS for the presence of drug metabolites during pre-clinical and clinical trials. Sample preparation for these analyses requires precipitating the plasma protein from solution, which is traditionally done by centrifugation. This application note presents results of plasma samples prepared with a fully-automated plasma protein precipitation sample preparation protocol using the MICROLAB® STAR and the Varian Captiva™ system.