Base Pair Biotechnologies Aptamers Combined with Vista Therapeutic’s NanoBioSensors™ for Biomarker Measurement in Human Serum

Aptamers are single-stranded DNA or RNA oligonucleotides selected to have unique three dimensional folding structure for binding to a variety of targets such as proteins, peptides, and even small molecules with affinity and specificity rivaling that of antibodies. They are typically selected in vitro by a process commonly referred to as “SELEX”. This application note demonstrate that some novel aptamers can bind to multiple targets simultaneously, using a proprietary variant of this process.