Benefits of Using ACQUITY QDa Mass Detection for Quantitative Analysis of Non-Chromophoric Memantine HCl in Tablet Formulation

In this application note, we describe the use of the ACQUITY QDa module, a small but robust, simple-to-use mass detector, to quantitate non-chromophoric memantine HCl, a drug commonly used to treat dementia often associated with Alzheimer’s disease. Here, we present a UPLC method coupled with the ACQUITY QDa Detector to quantitatively determine memantine HCl in the drug tablet formulation. We will demonstrate the system suitability, method linearity, and specificity achievable with mass detection for routine assays.