BIOshell Fused-Core Columns for Ultra Efficient RPLC of Proteins and Peptides

Columns packed with fully porous particles have long been considered normal for HPLC practitioners. Since 2006, Fused-Core^® or core-shell columns have caused a paradigm shift in the minds of liquid chromatographers who analyze small molecules. The benefits of porous-shell columns are now also available to scientists who are tasked to advance our knowledge about peptides, proteins and other biopolymers. This application note introduces how BIOshell Fused-Core Columns can be utilized for ultra efficient purification of proteins and peptides.